Literature DB >> 15780440

Evaluation of an intracellular-activated promoter for the generation of live Salmonella recombinant vaccines.

Mohamed I Husseiny1, Michael Hensel.   

Abstract

Salmonella enterica serovar Typhimurium is a versatile host organism for the generation of recombinant live vaccines for mucosal immunization. We investigated the performance of an intracellular-activated promoter for expression of heterologous antigens by Salmonella carrier strains. We observed that intracellular expressed antigens were more efficient in elicitation of humoral and cellular immune responses than constitutively expressed antigens. Furthermore, the intracellular-activated promoter was more efficient in combination with a carrier strain deficient in SPI2 gene sseC than with the conventional aroA strain. We propose that intracellular-activated promoters will be useful tools for construction of efficient recombinant live vaccines.

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Year:  2005        PMID： 15780440     DOI： 10.1016/j.vaccine.2004.11.035

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  10 in total

1.  Efficacy of intracellular activated promoters for generation of Salmonella-based vaccines.

Authors:  Xin Xu; Mohamed I Husseiny; Andreas Goldwich; Michael Hensel
Journal:  Infect Immun       Date:  2010-08-23       Impact factor: 3.441

2.  Rapid method for the construction of Salmonella enterica Serovar Typhimurium vaccine carrier strains.

Authors:  Mohamed I Husseiny; Michael Hensel
Journal:  Infect Immun       Date:  2005-03       Impact factor: 3.441

3.  Comparison of a regulated delayed antigen synthesis system with in vivo-inducible promoters for antigen delivery by live attenuated Salmonella vaccines.

Authors:  Shifeng Wang; Yuhua Li; Huoying Shi; Wei Sun; Kenneth L Roland; Roy Curtiss
Journal:  Infect Immun       Date:  2010-12-06       Impact factor: 3.441

4.  Systematic analysis of the SsrAB virulon of Salmonella enterica.

Authors:  Xin Xu; Michael Hensel
Journal:  Infect Immun       Date:  2009-10-26       Impact factor: 3.441

5.  Novel cancer vaccine based on genes of Salmonella pathogenicity island 2.

Authors:  Guosheng Xiong; Mohamed I Husseiny; Liping Song; Anat Erdreich-Epstein; Gregory M Shackleford; Robert C Seeger; Daniela Jäckel; Michael Hensel; Leonid S Metelitsa
Journal:  Int J Cancer       Date:  2010-06-01       Impact factor: 7.396

6.  Oral Salmonella msbB Mutant as a Carrier for a Salmonella-Based Vaccine for Prevention and Reversal of Type 1 Diabetes.

Authors:  Jacob Cobb; Jeffrey Rawson; Nelson Gonzalez; Michael Hensel; Fouad Kandeel; Mohamed I Husseiny
Journal:  Front Immunol       Date:  2021-05-24       Impact factor: 7.561

7.  LsrR-mediated quorum sensing controls invasiveness of Salmonella typhimurium by regulating SPI-1 and flagella genes.

Authors:  Jeongjoon Choi; Dongwoo Shin; Minjeong Kim; Joowon Park; Sangyong Lim; Sangryeol Ryu
Journal:  PLoS One       Date:  2012-05-18       Impact factor: 3.240

8.  Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice.

Authors:  Jacques C Mbongue; Jeffrey Rawson; Pablo A Garcia; Nelson Gonzalez; Jacob Cobb; Fouad Kandeel; Kevin Ferreri; Mohamed I Husseiny
Journal:  Front Immunol       Date:  2019-02-26       Impact factor: 7.561

9.  Development of a Fur-dependent and tightly regulated expression system in Escherichia coli for toxic protein synthesis.

Authors:  Lingyu Guan; Qin Liu; Chao Li; Yuanxing Zhang
Journal:  BMC Biotechnol       Date:  2013-03-19       Impact factor: 2.563

10.  Tracking of an Oral Salmonella-Based Vaccine for Type 1 Diabetes in Non-obese Diabetic Mice.

Authors:  Jacques C Mbongue; Ali Alhoshani; Jeffrey Rawson; Pablo A Garcia; Nelson Gonzalez; Kevin Ferreri; Fouad Kandeel; Mohamed I Husseiny
Journal:  Front Immunol       Date:  2020-04-28       Impact factor: 7.561
  10 in total

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