BACKGROUND: Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium. METHODS: The sialyl Lewis X (sL(X)) expression in 45 specimens from renal cell carcinoma patients was examined using immunohistochemistry. RESULTS: In this study, we demonstrate that the immunoreactivity for sL(X) in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma. CONCLUSION: Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sL(X) expression.
BACKGROUND: Interaction between tumor cells and endothelium plays a major role in cancer invasion and metastasis. Among various cell adhesion molecules, the cognate interaction between sialyl Lewis antigen expressed in the tumor cell surface and E-selectin expressed on endothelial cells is considered to be crucial for the tumor cell adhesion to the endothelium. METHODS: The sialyl Lewis X (sL(X)) expression in 45 specimens from renal cell carcinomapatients was examined using immunohistochemistry. RESULTS: In this study, we demonstrate that the immunoreactivity for sL(X) in renal cell carcinoma specimens not only correlates with conventional histopathologic parameters but also serves as a useful indicator for the prognosis of renal cell carcinoma. CONCLUSION: Since beneficial effect of cimetidine has been reported and ascribed to its inhibitory action on the expression of E-selectin, a ligand molecule of sialyl Lewis antigen, cimetidine may also show inhibitory effect on the tumor recurrence and metastasis of renal cell carcinoma with high level of sL(X) expression.
Authors: Thomas Kolben; Lena Müller; Sarah Meister; Lucia Keilmann; Christina Buschmann; Fabian Trillsch; Alexander Burges; Bastian Czogalla; Sophie Mitter; Elisa Schmoeckel; Stefanie Corradini; Sven Mahner; Udo Jeschke; Mirjana Kessler; Susanne Beyer Journal: J Cancer Res Clin Oncol Date: 2022-06-21 Impact factor: 4.322
Authors: Ke Zen; Dan-Qing Liu; Ya-Lan Guo; Chen Wang; Jun Shan; Ming Fang; Chen-Yu Zhang; Yuan Liu Journal: PLoS One Date: 2008-03-19 Impact factor: 3.240