| Literature DB >> 15777968 |
Anil Wali1, Patrice J Morin, Colleen D Hough, Fulvio Lonardo, Tsukasa Seya, Michele Carbone, Harvey I Pass.
Abstract
Malignant pleural mesothelioma (MPM) is a fatal neoplasm with no acceptable curative approaches. We used serial analysis of gene expression (SAGE) to compare the gene expression pattern of a surgically resected MPM to the autologous normal mesothelium. Intelectin gene overexpression (>139-fold) was found in the tumor. Online SAGE datasets revealed intelectin to be consistently present in mesothelioma(s), ovarian cancer, and colon cancer. Intelectin mRNA expression was found by RT-PCR in 4 of 5 resected MPM tumors, and Intelectin protein expression was confirmed by immunohistochemistry in 28 of 53 MPM tumors, and in 4 of 4 mesothelioma cell lines studied by Western blot. A marked induction in intelectin gene expression was observed among human primary mesothelial cells as a consequence of crocidolite asbestos exposure and simian virus 40 infection. Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications.Entities:
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Year: 2004 PMID： 15777968 DOI： 10.1016/j.lungcan.2004.10.011
Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705