Literature DB >> 1577665

Synthesis and activity of C-21 alkylamino derivatives of (9R)-erythromycylamine.

P A Lartey1, S L DeNinno, R Faghih, D J Hardy, J J Clement, J J Plattner.   

Abstract

Novel analogs of (9R)-9-deoxo-9-(N,N-dimethylamino)erythromycin A bearing N-alkylamino substituents at the C-21 position were synthesized. These compounds retained antibacterial activity. The C-21, N,N-dimethylamino analog showed a modest improvement in activity against some Gram-negative bacteria.

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Year:  1992        PMID: 1577665     DOI: 10.7164/antibiotics.45.380

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  1 in total

1.  Synthetic studies on erythromycin derivatives: reactivity of the C12-21 alkene.

Authors:  Wei-Min Chen
Journal:  Molecules       Date:  2006-01-31       Impact factor: 4.411

  1 in total

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