Literature DB >> 1577657

Galacardins A and B, new glycopeptide antibiotics.

M Takeuchi1, S Takahashi, R Enokita, Y Sakaida, H Haruyama, T Nakamura, T Katayama, M Inukai.   

Abstract

A strain of actinomycetes identified as Saccharothrix sp. SANK 64289 was found to produce new antibiotics, galacardins A and B. Their physico-chemical properties showed that they were new members of glycopeptide antibiotics. They were structurally related to beta-avoparcin but differed from it only in sugar composition. Though beta-avoparcin does not contain galactose, galacardins A and B did contain two and one moles of galactose, respectively. They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice.

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Year:  1992        PMID： 1577657     DOI： 10.7164/antibiotics.45.297

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.

Authors:  Ségolène Caboche; Valérie Leclère; Maude Pupin; Gregory Kucherov; Philippe Jacques
Journal:  J Bacteriol       Date:  2010-08-06       Impact factor: 3.490

Review 2.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

3.  Saccharothrix sp. PAL54, a new chloramphenicol-producing strain isolated from a Saharan soil.

Authors:  Adel Aouiche; Nasserdine Sabaou; Atika Meklat; Abdelghani Zitouni; Christian Bijani; Florence Mathieu; Ahmed Lebrihi
Journal:  World J Microbiol Biotechnol       Date:  2011-09-22       Impact factor: 3.312

4.  Biocontrol of toxinogenic Aspergillus flavus and Fusarium oxysporum f. sp. albedinis by two rare Saharan actinomycetes strains and LC-ESI/MS-MS profiling of their antimicrobial products.

Authors:  Hayate Meliani; Ahmed Makhloufi; Ameur Cherif; Mouna Mahjoubi; Khadidja Makhloufi
Journal:  Saudi J Biol Sci       Date:  2022-04-21       Impact factor: 4.052

5.  Bioprospecting of Soil-Derived Actinobacteria Along the Alar-Hotan Desert Highway in the Taklamakan Desert.

Authors:  Shaowei Liu; Ting Wang; Qinpei Lu; Feina Li; Gang Wu; Zhongke Jiang; Xugela Habden; Lin Liu; Xiaolin Zhang; Dmitry A Lukianov; Ilya A Osterman; Petr V Sergiev; Olga A Dontsova; Chenghang Sun
Journal:  Front Microbiol       Date:  2021-03-15       Impact factor: 5.640
  5 in total

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