Literature DB >> 15776563

Experimental infection of the skin in the hamster simulating human impetigo. III. Interaction between staphylococci and group A streptococci.

A S Dajani, L W Wannamaker.   

Abstract

The interaction between staphylococci and Group A beta hemolytic streptococci in mixed lesions was investigated in an experimental impetigo model. A strain of staphylococcus of phage Type 71, which has been shown in vitro to produce a bacteriocin for streptococci and other Gram-positive organisms, eliminates or reduces Group A streptococci in mixed lesions. In contrast, staphylococcal strains of phage Types 75 and 81, which do not produce a demonstrable bacteriocin in vitro, exhibit no such effect. Some variation was noted in the in vivo response of two different streptococcal M Types to the bactericidal effect of phage Type 71 staphylococci. Bacterial antagonism is more pronounced when staphylococci and streptococci are injected simultaneously into animals than when staphylococci are superimposed on preexisting streptococcal lesions. Marked variations were found in the numbers of viable streptococci (colony-forming units) recovered from individual lesions containing identical mixtures of streptococci and phage Type 71 staphylococci. The frequency of a demonstrable bactericidal effect was related to the number of streptococci injected. With small inocula of streptococci, the tendency towards an all-or-none effect was particularly striking. No evidence of selection of streptococcal or staphylococcal mutants which might explain this phenomenon was obtained. These observations suggest that the bactericidal effect of phage Type 71 staphylococci on other Gram-positive organisms, previously demonstrated in vitro, appears to operate also in vivo.

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Year:  1971        PMID: 15776563      PMCID: PMC2139072          DOI: 10.1084/jem.134.3.588

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  22 in total

1.  BACTERIAL INTERFERENCE; PROTECTION OF ADULTS AGAINST NASAL STAPHYLOCOCCUS AUREUS INFECTION AFTER COLONIZATION WITH A HETEROLOGOUS S AUREUS STRAIN.

Authors:  M BORIS; T F SELLERS; H F EICHENWALD; J C RIBBLE; H R SHINEFIELD
Journal:  Am J Dis Child       Date:  1964-09

2.  THE BACTERIOLOGIC FINDINGS, STREPTOCOCCAL IMMUNE RESPONSE, AND RENAL COMPLICATIONS IN CHILDREN AND IMPETIGO.

Authors:  M MARKOWITZ; H D BRUTON; A G KUTTNER; L E CLUFF
Journal:  Pediatrics       Date:  1965-03       Impact factor: 7.124

3.  Production of colicine by single bacteria.

Authors:  H OZEKI; B A STOCKER; H DE MARGERIE
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4.  Some cultural characteristics of Staphylococcus aureus strains from superficial skin infections.

Authors:  M T PARKER
Journal:  J Hyg (Lond)       Date:  1958-06

5.  Mixed bacterial infections in relation to antibiotic activities. I. Clostridium septicum-Micrococcus infections.

Authors:  S P HALBERT; C SONN; L SWICK
Journal:  J Immunol       Date:  1954-09       Impact factor: 5.422

6.  Effect of Bactericidal Substance from Staphylococcus aureus on Group A Streptococci II. Structural Alterations.

Authors:  C C Clawson; A S Dajani
Journal:  Infect Immun       Date:  1970-05       Impact factor: 3.441

7.  A mechanism of bacterial interference in vitro.

Authors:  J C Ribble
Journal:  J Immunol       Date:  1967-04       Impact factor: 5.422

Review 8.  Differences between streptococcal infections of the throat and of the skin (second of two parts).

Authors:  L W Wannamaker
Journal:  N Engl J Med       Date:  1970-01-08       Impact factor: 91.245

9.  The mouse intestinal microflora with emphasis on the strict anaerobes.

Authors:  A Lee; J Gordon; C J Lee; R Dubos
Journal:  J Exp Med       Date:  1971-02-01       Impact factor: 14.307

10.  Bacterial interference in experimental burns.

Authors:  B F Anthony; L W Wannamaker
Journal:  J Exp Med       Date:  1967-02-01       Impact factor: 14.307

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  7 in total

Review 1.  Yeast killer systems.

Authors:  W Magliani; S Conti; M Gerloni; D Bertolotti; L Polonelli
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

2.  Kinetic studies on the interaction of bacteriophage type 71 staphylococcal bacteriocin with susceptible bacteria.

Authors:  A S Dajani; L W Wannamaker
Journal:  J Bacteriol       Date:  1973-05       Impact factor: 3.490

Review 3.  Bacteriocins of gram-positive bacteria.

Authors:  J R Tagg; A S Dajani; L W Wannamaker
Journal:  Bacteriol Rev       Date:  1976-09

4.  Interactions between antibiotic-producing and non-producing staphylococci in skin surface and sub-surface models.

Authors:  W C Noble; J A Willie
Journal:  Br J Exp Pathol       Date:  1980-06

5.  Natural history of impetigo. II. Etiologic agents and bacterial interactions.

Authors:  A S Dajani; P Ferrieri; L W Wannamaker
Journal:  J Clin Invest       Date:  1972-11       Impact factor: 14.808

6.  Experimental infection of the skin in the hamster simulating human impetigo. IV. Cellular responses after streptococcal and staphylococcal infections.

Authors:  A S Dajani; L W Wannamaker
Journal:  Infect Immun       Date:  1972-06       Impact factor: 3.441

7.  Antibody responses to group A streptococcal infections in the hamster.

Authors:  A S Dajani; P Ferrieri; L W Wannamaker
Journal:  Infect Immun       Date:  1972-12       Impact factor: 3.441

  7 in total

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