Literature DB >> 15776189

Comparison between immunohistochemical expression of cyclin D1 and p21 and histological malignancy graduation of oral squamous cell carcinomas.

Adriana da Costa Neves1, Ricardo Alves Mesquita, Moacir Domingos Novelli, Edna Toddai, Suzana Orsini Machado De Sousa.   

Abstract

The objective of the present study was to correlate the expression of cyclin D1 with the expression of p21 in 28 cases of oral squamous cell carcinoma (OSCC), as well as to compare the expression of both with a histological graduation of this neoplasm. Immunohistochemistry was used to obtain the expression of cyclin D1 and p21. The results of statistical analysis showed no correlation between the expression of cyclin D1 and p21. Also, there was no correlation between the mean numbers of cyclin D1 positive nuclei and p21 positive nuclei and the histological scores of malignancy. However, the marked expression of cyclin D1 in high-grade tumors supports its role in proliferative activity. In contrast, p21 seems unable to arrest tumor progression in OSCC.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15776189     DOI： 10.1590/s0103-64402004000200002

Source DB:  PubMed          Journal:  Braz Dent J        ISSN： 0103-6440


  8 in total

1.  The prognostic implication of the expression of EGFR, p53, cyclin D1, Bcl-2 and p16 in primary locally advanced oral squamous cell carcinoma cases: a tissue microarray study.

Authors:  Monica Charlotte Solomon; M S Vidyasagar; Donald Fernandes; Vasudev Guddattu; Mary Mathew; Ankur Kaur Shergill; Sunitha Carnelio; Chetana Chandrashekar
Journal:  Med Oncol       Date:  2016-11-05       Impact factor: 3.064

2.  Cyclin d1 gene expression in oral mucosa of tobacco chewers"-an immunohistochemical study.

Authors:  Maharudrappa Basnaker; Srikala Sp; Satish Bnvs
Journal:  J Clin Diagn Res       Date:  2014-05-15

3.  Cyclin d1 expression and its correlation with histopathological differentiation in oral squamous cell carcinoma.

Authors:  Swati Saawarn; Madhusudan Astekar; Nisheeth Saawarn; Nidhi Dhakar; Shitalkumar Gomateshwar Sagari
Journal:  ScientificWorldJournal       Date:  2012-05-02

4.  Immunohistochemical Expression of Cyclin D1 and Ki-67 in Primary and Metastatic Oral Squamous Cell Carcinoma.

Authors:  Maryam Nazar; Iram Naz; Muhammad Khurram Mahmood; Shoaib Naiyer Hashmi
Journal:  Asian Pac J Cancer Prev       Date:  2020-01-01

5.  Cyclin D1 in oral premalignant lesions and oral squamous cell carcinoma: An immunohistochemical study.

Authors:  Rohit Balwant Moharil; Shubhangi Khandekar; Alka Dive; Ashish Bodhade
Journal:  J Oral Maxillofac Pathol       Date:  2020-09-09

6.  Immunohistochemical Expression of Epithelial Mesenchymal Transition Proteins in Squamous Cell Carcinoma of the Oral Cavity.

Authors:  Hamideh Kadeh; Shirin Saravani; Ebrahim Miri Moghaddam
Journal:  Iran J Pathol       Date:  2021-07-06

7.  Evaluation of the Role Played by Cyclin D1 as a Diagnostic and Prognostic Marker in the Progression of Oral Carcinogenesis.

Authors:  Reena Rachel John; C Ravindran; N Malathi; Rita Mary Aruna
Journal:  J Maxillofac Oral Surg       Date:  2018-01-29

Review 8.  The role of p21Waf1/CIP1 as a Cip/Kip type cell-cycle regulator in oral squamous cell carcinoma (Review).

Authors:  Mario Pérez-Sayáns; José-Manuel Suárez-Peñaranda; Pilar Gayoso-Diz; Francisco Barros-Angueira; José-Manuel Gándara-Rey; Abel García-García
Journal:  Med Oral Patol Oral Cir Bucal       Date:  2013-03-01
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.