M Maschke1, P J Tuite, K Pickett, T Wächter, J Konczak. 1. Sensorimotor Control Laboratory, Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA. matthias.maschke@uni-essen.de
Abstract
BACKGROUND: Parkinson's disease is accompanied by deficits in passive motion and limb position sense. OBJECTIVE: To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits. METHODS AND RESULTS: A passive movement task was applied to nine patients with Parkinson's disease and bilateral chronic STN-DBS and to seven controls. Thresholds for 75% correct responses were 0.9 degrees for controls, 2.5 degrees for Parkinson's disease patients when stimulation was OFF, and 2.0 degrees when stimulation was ON. CONCLUSIONS: STN-DBS improves kinaesthesic deficits in Parkinson's disease, but does not lead to a full recovery of proprioceptive function.
BACKGROUND:Parkinson's disease is accompanied by deficits in passive motion and limb position sense. OBJECTIVE: To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits. METHODS AND RESULTS: A passive movement task was applied to nine patients with Parkinson's disease and bilateral chronic STN-DBS and to seven controls. Thresholds for 75% correct responses were 0.9 degrees for controls, 2.5 degrees for Parkinson's diseasepatients when stimulation was OFF, and 2.0 degrees when stimulation was ON. CONCLUSIONS:STN-DBS improves kinaesthesic deficits in Parkinson's disease, but does not lead to a full recovery of proprioceptive function.
Authors: Matthias Maschke; Christopher M Gomez; Paul J Tuite; Kristen Pickett; Jürgen Konczak Journal: Exp Brain Res Date: 2006-05-30 Impact factor: 1.972