OBJECTIVE: To determine the morphologic characteristics of traumatic neuromas resulting from damage to the lingual nerve during the surgical removal of lower third molar teeth. STUDY DESIGN: Using light microscopy, we examined hematoxylin and eosin-stained sections of neuromas removed at the time of microsurgical nerve repair in 31 patients. Changes in fascicular pattern were quantified and evidence of inflammation was recorded. Statistical comparisons were made between the sections from patients with and without symptoms of dysesthesia, and with sections of normal lingual nerve obtained from organ donor retrieval patients. RESULTS: The neuromas were found to contain large numbers of small and haphazardly arranged regenerating nerve fascicles within a densely collagenous and fibroblastic stroma. The mean number of fascicles was 31 (+/- SD 28) in normal lingual nerve, but 462 (+/- 366) within traumatic neuromas. Mean fascicle diameter was 44 (+/- 10) microm in neuromas, but 273 (+/- 101) microm in normal nerve. A chronic mononuclear cell inflammatory infiltrate was observed in 42% of neuroma specimens, and histologic signs of inflammation were frequently seen in patients with symptoms of dysesthesia. CONCLUSIONS: Damage to the lingual nerve during third molar removal results in marked changes to the fascicular pattern and sometimes the presence of chronic inflammation in the injured nerve. These changes could contribute to the altered electrophysiological properties of axons trapped within traumatic neuromas, but we found no significant differences between the specimens studied from patients with or without symptoms of dysesthesia.
OBJECTIVE: To determine the morphologic characteristics of traumatic neuromas resulting from damage to the lingual nerve during the surgical removal of lower third molar teeth. STUDY DESIGN: Using light microscopy, we examined hematoxylin and eosin-stained sections of neuromas removed at the time of microsurgical nerve repair in 31 patients. Changes in fascicular pattern were quantified and evidence of inflammation was recorded. Statistical comparisons were made between the sections from patients with and without symptoms of dysesthesia, and with sections of normal lingual nerve obtained from organ donor retrieval patients. RESULTS: The neuromas were found to contain large numbers of small and haphazardly arranged regenerating nerve fascicles within a densely collagenous and fibroblastic stroma. The mean number of fascicles was 31 (+/- SD 28) in normal lingual nerve, but 462 (+/- 366) within traumatic neuromas. Mean fascicle diameter was 44 (+/- 10) microm in neuromas, but 273 (+/- 101) microm in normal nerve. A chronic mononuclear cell inflammatory infiltrate was observed in 42% of neuroma specimens, and histologic signs of inflammation were frequently seen in patients with symptoms of dysesthesia. CONCLUSIONS: Damage to the lingual nerve during third molar removal results in marked changes to the fascicular pattern and sometimes the presence of chronic inflammation in the injured nerve. These changes could contribute to the altered electrophysiological properties of axons trapped within traumatic neuromas, but we found no significant differences between the specimens studied from patients with or without symptoms of dysesthesia.
Authors: Emma V Bird; Claire R Christmas; Alison R Loescher; Keith G Smith; Peter P Robinson; Joel A Black; Stephen G Waxman; Fiona M Boissonade Journal: Mol Pain Date: 2013-10-21 Impact factor: 3.395
Authors: Karla M C Oliveira; Lukas Pindur; Zhihua Han; Mit B Bhavsar; John H Barker; Liudmila Leppik Journal: PLoS One Date: 2018-07-16 Impact factor: 3.240