Literature DB >> 15771893

Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.

Junsong Wang1, Yongtang Zheng, Thomas Efferth, Ruirui Wang, Yuemao Shen, Xiaojiang Hao.   

Abstract

A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.

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Year:  2005        PMID: 15771893     DOI: 10.1016/j.phytochem.2005.02.003

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  5 in total

Review 1.  Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.

Authors:  Ramandeep Kaur; Pooja Sharma; Girish K Gupta; Fidele Ntie-Kang; Dinesh Kumar
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

2.  Molecular biology of cantharidin in cancer cells.

Authors:  Rolf Rauh; Stefan Kahl; Herbert Boechzelt; Rudolf Bauer; Bernd Kaina; Thomas Efferth
Journal:  Chin Med       Date:  2007-07-04       Impact factor: 5.455

Review 3.  An Explorer of Chemical Biology of Plant Natural Products in Southwest China, Xiaojiang Hao.

Authors:  Yue-Mao Shen; Duo-Zhi Chen
Journal:  Nat Prod Bioprospect       Date:  2018-07-21

4.  Palladium-catalyzed synthesis of natural and unnatural 2-, 5-, and 7-oxygenated carbazole alkaloids from N-arylcyclohexane enaminones.

Authors:  Rafael Bautista; Pablo A Montoya; Araceli Rebollar; Eleuterio Burgueño; Joaquín Tamariz
Journal:  Molecules       Date:  2013-08-26       Impact factor: 4.411

5.  Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation.

Authors:  Jing-Hua Yang; Xin-Yi Wang; Yi-Ping Zhou; Rong Lu; Chin-Ho Chen; Meng-Han Zhang; Yung-Yi Cheng; Susan L Morris-Natschke; Kuo-Hsiung Lee; Yun-Song Wang
Journal:  Molecules       Date:  2019-12-26       Impact factor: 4.411

  5 in total

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