| Literature DB >> 15771488 |
Eita Sasaki1, Hirotatsu Kojima, Hiroaki Nishimatsu, Yasuteru Urano, Kazuya Kikuchi, Yasunobu Hirata, Tetsuo Nagano.
Abstract
Novel near-infrared (NIR) fluorescent probes for nitric oxide (NO) have been designed, synthesized, and evaluated. Their NIR fluorescence was increased in an NO concentration-dependent manner under physiological conditions, and their reaction efficiency with NO was at least 53 times higher than that of a widely used NO probe, DAF-2. They were confirmed to function in isolated intact rat kidneys. Because NIR light can penetrate deeply into tissues, these probes may have potential for in vivo NO imaging.Entities:
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Year: 2005 PMID: 15771488 DOI: 10.1021/ja042967z
Source DB: PubMed Journal: J Am Chem Soc ISSN: 0002-7863 Impact factor: 15.419