| Literature DB >> 15771449 |
Jerome Guillemont1, Elisabeth Pasquier, Patrice Palandjian, Daniel Vernier, Sandrine Gaurrand, Paul J Lewi, Jan Heeres, Marc R de Jonge, Lucien M H Koymans, Frits F D Daeyaert, Maarten H Vinkers, Eddy Arnold, Kalyan Das, Rudi Pauwels, Koen Andries, Marie-Pierre de Béthune, Eva Bettens, Kurt Hertogs, Piet Wigerinck, Philip Timmerman, Paul A J Janssen.
Abstract
This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis program around this new DAPY series was further optimized to produce compounds displaying improved activity against a panel of eight clinically relevant single and double mutant strains of human immunodeficiency virus type 1 (HIV-1).Entities:
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Year: 2005 PMID： 15771449 DOI： 10.1021/jm040838n
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446