| Literature DB >> 15770999 |
Olga Corti1, Cornelia Hampe, Frédéric Darios, Pablo Ibanez, Merle Ruberg, Alexis Brice.
Abstract
Parkinson's disease (PD) is a common age-related, progressive neurodegenerative disease of unknown etiology. Environmental factors have long been suspected to participate in the pathogenesis of PD due to the existence of neurotoxins that preferentially damage the dopaminergic nigrostriatal pathway. In the past few years, novel insights into the degenerative process have been provided by the discovery of genes responsible for rare monogenic parkinsonian syndromes. Compelling evidence is accumulating, suggesting that the products of several of these genes can interact with environmental toxins and intervene in molecular pathways controlling the functional integrity of mitochondria.Entities:
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Year: 2005 PMID： 15770999 DOI： 10.1016/j.crvi.2004.10.009
Source DB: PubMed Journal: C R Biol ISSN： 1631-0691 Impact factor: 1.583