Literature DB >> 15770421

Regulation of food intake by oleoylethanolamide.

J Lo Verme1, S Gaetani, J Fu, F Oveisi, K Burton, D Piomelli.   

Abstract

Oleoylethanolamide (OEA), the naturally occurring amide of ethanolamine and oleic acid, is an endogenous lipid that modulates feeding, body weight and lipid metabolism by binding with high affinity to the ligand-activated transcription factor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha). In the present article, we describe the biochemical pathways responsible for the initiation and termination of OEA signaling, and outline the pharmacological properties of this compound in relation to its ability to activate PPAR-alpha. Finally, we discuss the possible role of OEA as a peripheral satiety hormone.

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Year:  2005        PMID： 15770421     DOI： 10.1007/s00018-004-4494-0

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  16 in total

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Review 6.  Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

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8.  New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service.

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Review 9.  Infective endocarditis: an analysis based on strict case definitions.

Authors:  C F Von Reyn; B S Levy; R D Arbeit; G Friedland; C S Crumpacker
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  65 in total

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Review 2.  Gastrointestinal chemosensation: chemosensory cells in the alimentary tract.

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Review 5.  The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids.

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6.  'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.

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9.  No effect of an oleoylethanolamide-related phospholipid on satiety and energy intake: a randomised controlled trial of phosphatidylethanolamine.

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10.  GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell.

Authors:  Lina M Lauffer; Roman Iakoubov; Patricia L Brubaker
Journal:  Diabetes       Date:  2009-02-10       Impact factor: 9.461
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