Literature DB >> 15770274

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins.

María Pérez1, Felipe Lombó, Lili Zhu, Miranda Gibson, Alfredo F Braña, Jurgen Rohr, José A Salas, Carmen Méndez.   

Abstract

L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

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Year:  2005        PMID： 15770274     DOI： 10.1039/b417815g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Engineered biosynthesis of macrolide derivatives bearing the non-natural deoxysugars 4-epi-D-mycaminose and 3-n-monomethylamino-3-deoxy-D-fucose.

Authors:  Charles E Melançon; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2007-03-28       Impact factor: 15.419

2.  Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT.

Authors:  S Eric Nybo; Khaled A Shabaan; Madan K Kharel; Happy Sutardjo; José A Salas; Carmen Méndez; Jürgen Rohr
Journal:  Bioorg Med Chem Lett       Date:  2012-02-03       Impact factor: 2.823

3.  Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses.

Authors:  María Pérez; Felipe Lombó; Irfan Baig; Alfredo F Braña; Jürgen Rohr; José A Salas; Carmen Méndez
Journal:  Appl Environ Microbiol       Date:  2006-10       Impact factor: 4.792

4.  Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.

Authors:  Aaroa P Salas; Lili Zhu; César Sánchez; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal:  Mol Microbiol       Date:  2005-10       Impact factor: 3.501

5.  Recombinant E. coli prototype strains for in vivo glycorandomization.

Authors:  Gavin J Williams; Jie Yang; Changsheng Zhang; Jon S Thorson
Journal:  ACS Chem Biol       Date:  2010-10-22       Impact factor: 5.100

6.  Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.

Authors:  Angelina Ramos; Carlos Olano; Alfredo F Braña; Carmen Méndez; José A Salas
Journal:  J Bacteriol       Date:  2009-02-20       Impact factor: 3.490

7.  Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification.

Authors:  Katelyn V Brown; Benjamin Nji Wandi; Mikko Metsä-Ketelä; S Eric Nybo
Journal:  J Org Chem       Date:  2020-09-22       Impact factor: 4.354

Review 8.  Natural-product sugar biosynthesis and enzymatic glycodiversification.

Authors:  Christopher J Thibodeaux; Charles E Melançon; Hung-wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

9.  Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.

Authors:  María Pérez; Irfan Baig; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Journal:  Chembiochem       Date:  2008-09-22       Impact factor: 3.164

10.  A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Authors:  Luz E Núñez; Stephen E Nybo; Javier González-Sabín; María Pérez; Nuria Menéndez; Alfredo F Braña; Khaled A Shaaban; Min He; Francisco Morís; José A Salas; Jürgen Rohr; Carmen Méndez
Journal:  J Med Chem       Date:  2012-06-07       Impact factor: 7.446
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