Literature DB >> 15769970

The prospect of silencing disease using RNA interference.

Premlata Shankar1, N Manjunath, Judy Lieberman.   

Abstract

The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therapeutic applications. In this article we discuss the basic mechanism of RNAi and the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease.

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Year:  2005        PMID： 15769970     DOI： 10.1001/jama.293.11.1367

Source DB:  PubMed          Journal:  JAMA        ISSN： 0098-7484            Impact factor:   56.272


  35 in total

Review 1.  RNA interference: ready to silence cancer?

Authors:  Simone Mocellin; Rodolfo Costa; Donato Nitti
Journal:  J Mol Med (Berl)       Date:  2005-11-09       Impact factor: 4.599

Review 2.  Silence of the transcripts: RNA interference in medicine.

Authors:  Sailen Barik
Journal:  J Mol Med (Berl)       Date:  2005-07-19       Impact factor: 4.599

3.  RNA interference with special reference to combating viruses of crustacea.

Authors:  Kathy La Fauce; Leigh Owens
Journal:  Indian J Virol       Date:  2012-08-14

Review 4.  RNA interference: a potent technology in studying and modulating of dendritic cells, and potential in clinical therapy.

Authors:  Fang Cheng; Song He
Journal:  Mol Biol Rep       Date:  2009-09-12       Impact factor: 2.316

5.  Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.

Authors:  Sandesh Subramanya; Sang-Soo Kim; Sojan Abraham; Jiahong Yao; Mukesh Kumar; Priti Kumar; Viraga Haridas; Sang-Kyung Lee; Leonard D Shultz; Dale Greiner; Manjunath N; Premlata Shankar
Journal:  J Virol       Date:  2009-12-16       Impact factor: 5.103

6.  Novel ultrasound-targeted microbubble destruction mediated short hairpin RNA plasmid transfection targeting survivin inhibits gene expression and induces apoptosis of HeLa cells.

Authors:  Zhiyi Chen; Kun Liang; Mingxing Xie; Xinfang Wang; Qing Lü; Jing Zhang
Journal:  Mol Biol Rep       Date:  2008-11-09       Impact factor: 2.316

Review 7.  RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?

Authors:  Sandesh Subramanya; Sang-Soo Kim; N Manjunath; Premlata Shankar
Journal:  Expert Opin Biol Ther       Date:  2010-02       Impact factor: 4.388

8.  In vitro and in vivo targeted delivery of IL-10 interfering RNA by JC virus-like particles.

Authors:  Meng-Ing Chou; Yu-Fan Hsieh; Meilin Wang; Jinghua Tsai Chang; Deching Chang; Moncef Zouali; Gregory J Tsay
Journal:  J Biomed Sci       Date:  2010-06-24       Impact factor: 8.410

9.  Delivery of RNAi reagents in murine models of obesity and diabetes.

Authors:  Denise M Wilcox; Ruojing Yang; Sherry J Morgan; Phong T Nguyen; Martin J Voorbach; Paul M Jung; Deanna L Haasch; Emily Lin; Eugene N Bush; Terry J Opgenorth; Peer B Jacobson; Christine A Collins; Cristina M Rondinone; Terry Surowy; Katherine T Landschulz
Journal:  J RNAi Gene Silencing       Date:  2006-11-29

10.  A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs.

Authors:  Olivier ter Brake; Ben Berkhout
Journal:  J RNAi Gene Silencing       Date:  2005-10-14
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