| Literature DB >> 15767456 |
Pilar Perez-Romero1, Aleida Perez, Althea Capul, Rebecca Montgomery, A Oveta Fuller.
Abstract
We examined herpes simplex virus (HSV)-infected human HEp-2 cells or porcine cells that express herpes virus entry mediator (HVEM) for virus and receptor protein interactions. Antibody to HVEM, or its viral ligand gD, coimmunoprecipitated several similar proteins. A prominent 110-kDa protein that coprecipitated was identified as gH. The HVEM/gD/gH complex was detected with mild or stringent cell lysis conditions. It did not form in cells infected with HSV-1(KOS)Rid1 virus or with null virus lacking gD, gH, or gL. Thus, in cells a complex forms through physical associations of HVEM, gD, and at least gH.Entities:
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Year: 2005 PMID: 15767456 PMCID: PMC1061527 DOI: 10.1128/JVI.79.7.4540-4544.2005
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103