Literature DB >> 15767456

Herpes simplex virus entry mediator associates in infected cells in a complex with viral proteins gD and at least gH.

Pilar Perez-Romero1, Aleida Perez, Althea Capul, Rebecca Montgomery, A Oveta Fuller.   

Abstract

We examined herpes simplex virus (HSV)-infected human HEp-2 cells or porcine cells that express herpes virus entry mediator (HVEM) for virus and receptor protein interactions. Antibody to HVEM, or its viral ligand gD, coimmunoprecipitated several similar proteins. A prominent 110-kDa protein that coprecipitated was identified as gH. The HVEM/gD/gH complex was detected with mild or stringent cell lysis conditions. It did not form in cells infected with HSV-1(KOS)Rid1 virus or with null virus lacking gD, gH, or gL. Thus, in cells a complex forms through physical associations of HVEM, gD, and at least gH.

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Year:  2005        PMID: 15767456      PMCID: PMC1061527          DOI: 10.1128/JVI.79.7.4540-4544.2005

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  40 in total

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Authors:  J C Whitbeck; C Peng; H Lou; R Xu; S H Willis; M Ponce de Leon; T Peng; A V Nicola; R I Montgomery; M S Warner; A M Soulika; L A Spruce; W T Moore; J D Lambris; P G Spear; G H Cohen; R J Eisenberg
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

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Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

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Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

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  26 in total

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Authors:  Ordel J Brown; Santiago A Lopez; A Oveta Fuller; Theodore Goodson
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Journal:  J Virol       Date:  2009-12-09       Impact factor: 5.103

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