| Literature DB >> 1576671 |
Y Sato1, Y Sakakibara, T Oda, E Aizu-Yokota, K Ichinoseki.
Abstract
The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 microM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.Entities:
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Year: 1992 PMID： 1576671 DOI： 10.1248/cpb.40.182
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645