Literature DB >> 15765141

Illuminating the role of type I IFNs in colitis.

Stefan Wirtz1, Markus F Neurath.   

Abstract

Recently, type I interferons IFN-alpha and IFN-beta (IFN-alpha/beta) have been evaluated in pilot clinical trials for the treatment of active ulcerative colitis. However, the underlying mechanisms that may contribute to a potential therapeutic effect are incompletely understood. A new study in this issue demonstrates a protective role for IFN-alpha/beta, induced by activation of a Toll-like receptor 9-dependent pathway, in a rodent model of experimental colitis.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15765141      PMCID： PMC1052017          DOI： 10.1172/JCI24518

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  20 in total

1.  Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties.

Authors:  Janine Bilsborough; Thaddeus C George; Anne Norment; Joanne L Viney
Journal:  Immunology       Date:  2003-04       Impact factor: 7.397

2.  Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.

Authors:  R Atreya; J Mudter; S Finotto; J Müllberg; T Jostock; S Wirtz; M Schütz; B Bartsch; M Holtmann; C Becker; D Strand; J Czaja; J F Schlaak; H A Lehr; F Autschbach; G Schürmann; N Nishimoto; K Yoshizaki; H Ito; T Kishimoto; P R Galle; S Rose-John; M F Neurath
Journal:  Nat Med       Date:  2000-05       Impact factor: 53.440

3.  An open-labeled, randomized study comparing systemic interferon-alpha-2A and prednisolone enemas in the treatment of left-sided ulcerative colitis.

Authors:  S M Madsen; P Schlichting; B Davidsen; O H Nielsen; B Federspiel; P Riis; P Munkholm
Journal:  Am J Gastroenterol       Date:  2001-06       Impact factor: 10.864

4.  Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.

Authors:  Kyoko Katakura; Jongdae Lee; Daniel Rachmilewitz; Gloria Li; Lars Eckmann; Eyal Raz
Journal:  J Clin Invest       Date:  2005-03       Impact factor: 14.808

5.  Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis.

Authors:  Daniel Rachmilewitz; Fanny Karmeli; Kenji Takabayashi; Tomoko Hayashi; Leonor Leider-Trejo; Jongdae Lee; Lorenzo M Leoni; Eyal Raz
Journal:  Gastroenterology       Date:  2002-05       Impact factor: 22.682

Review 6.  Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease.

Authors:  S Wirtz; M F Neurath
Journal:  Int J Colorectal Dis       Date:  2000-06       Impact factor: 2.571

7.  Interferon beta-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating study.

Authors:  S Nikolaus; P Rutgeerts; R Fedorak; A H Steinhart; G E Wild; D Theuer; J Möhrle; S Schreiber
Journal:  Gut       Date:  2003-09       Impact factor: 23.059

8.  CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice.

Authors:  Florian Obermeier; Nadja Dunger; Ludwig Deml; Hans Herfarth; Jürgen Schölmerich; Werner Falk
Journal:  Eur J Immunol       Date:  2002-07       Impact factor: 5.532

9.  Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis.

Authors:  F Obermeier; N Dunger; U G Strauch; N Grunwald; H Herfarth; J Schölmerich; W Falk
Journal:  Clin Exp Immunol       Date:  2003-11       Impact factor: 4.330

10.  IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.

Authors:  M K Levings; R Sangregorio; F Galbiati; S Squadrone; R de Waal Malefyt; M G Roncarolo
Journal:  J Immunol       Date:  2001-05-01       Impact factor: 5.422
View more
  10 in total

1.  Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients.

Authors:  Henri Braat; Pieter Stokkers; Tijmen Hommes; Danny Cohn; Esther Vogels; Inge Pronk; Arnold Spek; Antoine van Kampen; Sander van Deventer; Maikel Peppelenbosch; Daan Hommes
Journal:  J Mol Med (Berl)       Date:  2005-07-12       Impact factor: 4.599

2.  Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis.

Authors:  D C Baumgart; D Metzke; O Guckelberger; A Pascher; C Grötzinger; I Przesdzing; Y Dörffel; J Schmitz; S Thomas
Journal:  Clin Exp Immunol       Date:  2011-07-15       Impact factor: 4.330

3.  Gut IgA abundance in adult life is a major determinant of resistance to dextran sodium sulfate-colitis and can compensate for the effects of inadequate maternal IgA received by neonates.

Authors:  Suman Gupta; Srijani Basu; Vineeta Bal; Satyajit Rath; Anna George
Journal:  Immunology       Date:  2019-07-03       Impact factor: 7.397

4.  Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.

Authors:  Steve Searles; Katherine Gauss; Michelle Wilkison; Teri R Hoyt; Erin Dobrinen; Nicole Meissner
Journal:  J Immunol       Date:  2013-08-23       Impact factor: 5.422

5.  Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis.

Authors:  Zhongliang Ju; Sangeeta S Chavan; Daniel J Antoine; Meghan Dancho; Teá Tsaava; Jianhua Li; Ben Lu; Yaakov A Levine; Andrew Stiegler; Yehuda Tamari; Yousef Al-Abed; Jesse Roth; Kevin J Tracey; Huan Yang
Journal:  PLoS One       Date:  2014-08-15       Impact factor: 3.240

Review 6.  Toll-like Receptors and Inflammatory Bowel Disease.

Authors:  Yue Lu; Xinrui Li; Shanshan Liu; Yifan Zhang; Dekai Zhang
Journal:  Front Immunol       Date:  2018-01-30       Impact factor: 7.561

7.  Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA.

Authors:  Christian D Sadik; Malte Bachmann; Josef Pfeilschifter; Heiko Mühl
Journal:  Nucleic Acids Res       Date:  2009-06-18       Impact factor: 16.971

8.  Generation of mouse small intestinal epithelial cell lines that allow the analysis of specific innate immune functions.

Authors:  Johannes Schwerk; Mario Köster; Hansjörg Hauser; Manfred Rohde; Marcus Fulde; Mathias W Hornef; Tobias May
Journal:  PLoS One       Date:  2013-08-05       Impact factor: 3.240

Review 9.  Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies.

Authors:  Amandip Kaur; Paraskevi Goggolidou
Journal:  J Inflamm (Lond)       Date:  2020-04-21       Impact factor: 4.981

10.  PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota.

Authors:  Lumin Wei; Rongjing Zhang; Jinzhao Zhang; Juanjuan Li; Deping Kong; Qi Wang; Jing Fang; Lifu Wang
Journal:  Mucosal Immunol       Date:  2021-08-04       Impact factor: 7.313
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.