BACKGROUND: Anemia in patients with COPD and its pathophysiology is an understudied issue. METHODS: In a group of 101 COPD patients (FEV(1) percentage of predicted, 37 +/- 2% [mean +/- SEM]; mean age, 61 +/- 1 years; 35% female gender), the prevalence of anemia and its relationship to body mass and weight loss, inflammatory parameters, and erythropoietin levels was determined. Data were compared to a control group (healthy persons with matched age) in order to identify potential factors that may influence the development of anemia in patients with COPD. RESULTS: Anemia was diagnosed in 13 patients (hemoglobin levels < 13.5 mg/dL in male patients and < 12.0 mg/dL in female patients), which represents a prevalence of 13%. Anemic COPD patients showed elevated erythropoietin levels (41.8 +/- 25.4 U/L vs 16.3 +/- 2.9 U/L) and an increased inflammatory response compared to nonanemic patients. A significant inverse correlation of hemoglobin vs erythropoietin (r = - 0.84, p < 0.01) was observed in anemic COPD patients, but not in the nonanemic group. CONCLUSION: Anemic COPD patients show high erythropoietin levels, which may indicate presence of erythropoietin resistance. The latter may be mediated through inflammatory mechanisms, which is typical for anemia of chronic illness.
BACKGROUND:Anemia in patients with COPD and its pathophysiology is an understudied issue. METHODS: In a group of 101 COPDpatients (FEV(1) percentage of predicted, 37 +/- 2% [mean +/- SEM]; mean age, 61 +/- 1 years; 35% female gender), the prevalence of anemia and its relationship to body mass and weight loss, inflammatory parameters, and erythropoietin levels was determined. Data were compared to a control group (healthy persons with matched age) in order to identify potential factors that may influence the development of anemia in patients with COPD. RESULTS:Anemia was diagnosed in 13 patients (hemoglobin levels < 13.5 mg/dL in male patients and < 12.0 mg/dL in female patients), which represents a prevalence of 13%. Anemic COPDpatients showed elevated erythropoietin levels (41.8 +/- 25.4 U/L vs 16.3 +/- 2.9 U/L) and an increased inflammatory response compared to nonanemic patients. A significant inverse correlation of hemoglobin vs erythropoietin (r = - 0.84, p < 0.01) was observed in anemic COPDpatients, but not in the nonanemic group. CONCLUSION:Anemic COPDpatients show high erythropoietin levels, which may indicate presence of erythropoietin resistance. The latter may be mediated through inflammatory mechanisms, which is typical for anemia of chronic illness.
Authors: Mauro Tettamanti; Ugo Lucca; Francesca Gandini; Angela Recchia; Paola Mosconi; Giovanni Apolone; Alessandro Nobili; Maria Vittoria Tallone; Paolo Detoma; Adriano Giacomin; Mario Clerico; Patrizia Tempia; Luigi Savoia; Gilberto Fasolo; Luisa Ponchio; Matteo G Della Porta; Emma Riva Journal: Haematologica Date: 2010-06-09 Impact factor: 9.941
Authors: Fernando J Martinez; Gregory Foster; Jeffrey L Curtis; Gerard Criner; Gail Weinmann; Alfred Fishman; Malcolm M DeCamp; Joshua Benditt; Frank Sciurba; Barry Make; Zab Mohsenifar; Philip Diaz; Eric Hoffman; Robert Wise Journal: Am J Respir Crit Care Med Date: 2006-03-16 Impact factor: 21.405
Authors: Suzanne M Cloonan; Sharon Mumby; Ian M Adcock; Augustine M K Choi; Kian Fan Chung; Gregory J Quinlan Journal: Am J Respir Crit Care Med Date: 2017-11-01 Impact factor: 21.405