| Literature DB >> 15763992 |
Mario M D'Elios1, Amedeo Amedei, Annalisa Azzurri, Marisa Benagiano, Gianfranco Del Prete, Mathijs P Bergman, Christina M Vandenbroucke-Grauls, Ben J Appelmelk.
Abstract
Human autoimmune gastritis (AIG) is a chronic inflammatory disorder of the gastric corpus. We have defined the antigen repertoire and the functional properties of in vivo activated CD4+ T cells derived from the gastric mucosa of patients with AIG. A remarkable proportion of the CD4+ T cell clones proliferated in response to H+,K+-ATPase. Six epitopes identified in the alpha chain, and 5 in the beta chain, of gastric K+,K+-ATPase were recognized by autoreactive gastric T cell clones. The majority of the autoreactive T cell clones secreted IFN-gamma and showed a T helper 1 (Th1) profile. All clones produced TNF-alpha,provided help for B cell immunoglobulin production, expressed perforin-mediated cytotoxicity, and most induced Fas-Fas ligand-mediated apoptosis. Data suggest that activation of gastric H+,K+-ATPase-specific Th1 T cells is crucial in the pathogenesis of human gastric autoimmunity and atrophy.Entities:
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Year: 2005 PMID： 15763992 DOI： 10.1080/08830180590884611
Source DB: PubMed Journal: Int Rev Immunol ISSN： 0883-0185 Impact factor: 5.311