Literature DB >> 15762765

A chiral cyclohexanone linked to polystyrene for solid-phase synthesis of chiral alpha-carbonyls.

Claude Spino1, Vitthal Genbhau Gund, Christian Nadeau.   

Abstract

Two chiral cyclohexanones were linked to polystyrene resin. The polymer-bound auxiliaries were subjected to a sequence of four reactions, the last of which cleaves the desired alpha-chiral carbonyl compound off the resin, concurrently regenerating the resin-bound auxiliary in its original form. The resin can then be reused.

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Year:  2005        PMID: 15762765     DOI: 10.1021/cc049859t

Source DB:  PubMed          Journal:  J Comb Chem        ISSN: 1520-4766


  1 in total

1.  Non-cross-linked polystyrene-supported 2-imidazolidinone chiral auxiliary: synthesis and application in asymmetric alkylation reactions.

Authors:  Quynh Pham Bao Nguyen; Taek Hyeon Kim
Journal:  Beilstein J Org Chem       Date:  2013-10-15       Impact factor: 2.883

  1 in total

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