Literature DB >> 1576056

Formation of biologically active 13,14-dihydro-prostaglandin E1 during intravenous infusion of prostaglandin E1 in newborns with ductus arteriosus-dependent congenital heart disease.

A Leonhardt1, H Schweer, D Wolf, H W Seyberth.   

Abstract

Plasma concentrations of prostaglandin (PG) E1 (12-150, median 25 pg ml-1) and 13,14-dihydro-PGE1 (3-62, median 45.5 pg ml-1) were measured by gas chromatography-mass spectrometry in eight newborns with ductus arteriosus-dependent congenital heart disease during continuous intravenous infusion of PGE1. Formation of 13,14-dihydro-PGE1 was demonstrated for the first time in neonates. Since 13,14-dihydro-PGE1 has similar biological activities as the parent compound PGE1, pharmacological effects during PGE1 infusion are most likely related to both PGE1 and the generation and action of 13,14-dihydro-PGE1.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1576056      PMCID： PMC1381284          DOI： 10.1111/j.1365-2125.1992.tb04044.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  19 in total

1.  PROSTAGLANDINS AND RELATED FACTORS. 28. METABOLISM OF PROSTAGLANDIN E1 IN GUINEA PIG LUNG: THE STRUCTURES OF TWO METABOLITES.

Authors:  B SAMUELSSON
Journal:  J Biol Chem       Date:  1964-12       Impact factor: 5.157

Review 2.  Prostaglandins and extracorporeal circulation.

Authors:  M B Starling; J M Neutze
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  1990-05       Impact factor: 4.006

Review 3.  The therapeutic value of vasodilator prostaglandins in multiple organ failure associated with sepsis.

Authors:  D J Bihari; J Tinker
Journal:  Intensive Care Med       Date:  1988       Impact factor: 17.440

4.  Prostaglandin E1 in the adult respiratory distress syndrome. Benefit for pulmonary hypertension and cost for pulmonary gas exchange.

Authors:  C Mélot; P Lejeune; M Leeman; J J Moraine; R Naeije
Journal:  Am Rev Respir Dis       Date:  1989-01

5.  Pulmonary extraction and pharmacokinetics of prostaglandin E1 during continuous intravenous infusion in patients with adult respiratory distress syndrome.

Authors:  J W Cox; N A Andreadis; R C Bone; R J Maunder; R H Pullen; J J Ursprung; M J Vassar
Journal:  Am Rev Respir Dis       Date:  1988-01

6.  The biological activities of three metabolites of prostaglandin E 1.

Authors:  E Anggård
Journal:  Acta Physiol Scand       Date:  1966-04

7.  Pharmacologically active levels of PGE1 in neonates with congenital heart disease.

Authors:  A Leonhardt; P G Kühl; H Schweer; D Wolf; H W Seyberth
Journal:  Acta Paediatr Scand       Date:  1989-11

Review 8.  Prostacyclin and PGE1 treatment of pulmonary hypertension.

Authors:  W A Long; L J Rubin
Journal:  Am Rev Respir Dis       Date:  1987-09

9.  Simultaneous determination of prostanoids in plasma by gas chromatography-negative-ion chemical-ionization mass spectrometry.

Authors:  H Schweer; J Kammer; H W Seyberth
Journal:  J Chromatogr       Date:  1985-03-22

10.  Beneficial effect of long-term PGE1-treatment in left ventricular heart failure.

Authors:  I Virgolini; J Kaliman; P Fitscha; J O'Grady; W Rogatti; H Sinzinger
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  1989-12       Impact factor: 4.006
View more
  1 in total

1.  Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects.

Authors:  W Cawello; H Schweer; R Müller; R Bonn; H W Seyberth
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.