| Literature DB >> 15760233 |
Charnsak Thongsornkleeb1, Rick L Danheiser.
Abstract
A general method for the preparation of 2-alkynyl acroleins is described beginning with vinyl iodide 5 and involving a combination of Sonogashira coupling and Dess-Martin oxidation. Critical to the success of this approach is the use of a special workup procedure for the oxidation step. The resultant enynals participate in a variety of addition reactions including aldol condensations and reactions with organolithium compounds.Entities:
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Year: 2005 PMID： 15760233 PMCID： PMC2897060 DOI： 10.1021/jo047869a
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354