Literature DB >> 15758459

Why should many skeletal scientists and clinicians learn the Utah paradigm of skeletal physiology?

H M Frost1.   

Abstract

Adding later facts and ideas to a universally accepted "1960 paradigm" of skeletal physiology led to the still-evolving "Utah paradigm". The ASBMR's William Neuman award in 2001 to one of the latter paradigm's architects (HMF) suggested that physiologists began to view it as a valid supplement to its predecessor. Nevertheless it diffused poorly among most SSCs (Skeletal Scientists and Clinicians, plus all others who work in any way on skeletal matters), even though success in the quest for knowledge and recognition by many of them could depend on learning that paradigm's insights. Those insights can help to minimize serious errors in some experimental designs and in interpreting some kinds of data. To explain how success in that quest could depend on the Utah paradigm requires explaining the nature of the above errors, some features of both paradigms, some implications of the newer one, and when that quest's success might not require knowing the Utah paradigm. A three-part message distilled from the past for present and future SSCs concludes the article. It took decades to understand such things and find effective ways to explain them, and both matters probably need improvement (to paraphrase Pogo, "We met the enemy and perhaps it was us more than them"). During those decades the author changed from an active SSC hunter-player to a spectator, known to some as a feisty eccentric old dinosaur (FEOD) (Note A). So here a voice from the past would speak to present and future SSCs.

Entities:  

Year:  2001        PMID: 15758459

Source DB:  PubMed          Journal:  J Musculoskelet Neuronal Interact        ISSN: 1108-7161            Impact factor:   2.041


  7 in total

Review 1.  Analyses of muscular mass and function: the impact on bone mineral density and peak muscle mass.

Authors:  Oliver Fricke; Ralf Beccard; Oliver Semler; Eckhard Schoenau
Journal:  Pediatr Nephrol       Date:  2010-05-11       Impact factor: 3.714

2.  Changes in proximal femoral mineral geometry precede the onset of radiographic hip osteoarthritis: The study of osteoporotic fractures.

Authors:  M K Javaid; N E Lane; D C Mackey; L-Y Lui; N K Arden; T J Beck; M C Hochberg; M C Nevitt
Journal:  Arthritis Rheum       Date:  2009-07

Review 3.  Bone regeneration and stem cells.

Authors:  K Arvidson; B M Abdallah; L A Applegate; N Baldini; E Cenni; E Gomez-Barrena; D Granchi; M Kassem; Y T Konttinen; K Mustafa; D P Pioletti; T Sillat; A Finne-Wistrand
Journal:  J Cell Mol Med       Date:  2011-04       Impact factor: 5.310

Review 4.  Innovative Biomaterials for Bone Regrowth.

Authors:  Maria Rosa Iaquinta; Elisa Mazzoni; Marco Manfrini; Antonio D'Agostino; Lorenzo Trevisiol; Riccardo Nocini; Leonardo Trombelli; Giovanni Barbanti-Brodano; Fernanda Martini; Mauro Tognon
Journal:  Int J Mol Sci       Date:  2019-01-31       Impact factor: 5.923

5.  Age-related trabecular bone loss is associated with a decline in serum Galectin-1 level.

Authors:  Wenting Xu; Cheng Ni; Yuxuan Wang; Guoqing Zheng; Jinshan Zhang; Youjia Xu
Journal:  BMC Musculoskelet Disord       Date:  2021-04-27       Impact factor: 2.362

6.  HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice.

Authors:  Chao Ma; Juan Gao; Jun Liang; Weixiang Dai; Zhenfei Wang; Mengjiao Xia; Tao Chen; Sen Huang; Jian Na; Long Xu; Shiming Feng; Kerong Dai; Guangwang Liu
Journal:  Stem Cell Res Ther       Date:  2021-08-28       Impact factor: 6.832

7.  The Biomechanical Profile of an Osseo-Integrated Rectangular Block Implant: A Pilot In Vivo Strain Analysis.

Authors:  Efthimios Gazelakis; Roy B Judge; Joseph E A Palamara; Mohsin Nazir
Journal:  Bioengineering (Basel)       Date:  2022-08-30
  7 in total

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