| Literature DB >> 15757658 |
Séverine Van Slambrouck1, Virinder S Parmar, Sunil K Sharma, Bart De Bondt, Fleur Foré, Peter Coopman, Barbara W Vanhoecke, Tom Boterberg, Herman T Depypere, Guy Leclercq, Marc E Bracke.
Abstract
Tangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary cancer cells and cytolysis by natural killer cells. Attempting to unravel the flavonoid's action mechanism, we found that it inhibited extracellular-signal-regulated kinases 1/2 (ERK1/2) phosphorylation in a dose- and time-dependent way. In human T47D mammary cancer cells this inhibition was optimally observed after priming with estradiol. The spectrum of the intracellular signalling kinase inhibition was narrow and comparison of structural congeners showed that inhibition of ERK phosphorylation was not unique for tangeretin. Our data add tangeretin to the list of small kinase inhibitors with a restricted intracellular inhibition profile.Entities:
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Year: 2005 PMID： 15757658 DOI： 10.1016/j.febslet.2004.10.114
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124