| Literature DB >> 15755503 |
Takashi Kumagai1, Ayalew Tefferi, Letetia Jones, H Phillip Koeffler.
Abstract
Promoter hypermethylation represents a primary mechanism in the inactivation of tumor suppressor genes during tumorigenesis. We analyzed the promoter methylation status of eight tumor-associated genes (p14 ARF, p15 INK4B, p16 INK4A, Rb, hMLH1, hMSH2, APC, and DAPK) in 30 patients with myelofibrosis with myeloid metaplasia (MMM) by methylation specific PCR. The study showed no hypermethylation of the promoters of p16(INK4A), Rb, hMLH1, hMSH2, APC, and DAPK genes. The p14 ARF, p15 INK4B promoters were hypermethylated in only one patient each. This study indicates that, although methylation of these genes is important in other cancers, it is rare in MMM and causation of this disease should be focused elsewhere.Entities:
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Year: 2005 PMID： 15755503 DOI： 10.1016/j.leukres.2004.11.002
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156