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Literature DB >> 1575478

Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin.

Abstract

The fatty acid synthase inhibitor cerulenin (50 to 100 micrograms/ml) inhibited production of the polyketide mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) by the mold Alternaria alternata. The results suggested that AOH synthesis was inhibited by a direct mechanism by cerulenin, whereas production of AME was probably limited by a shortage of the precursor AOH.

Entities: Chemical Species

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Year: 1992 PMID： 1575478 PMCID： PMC195377 DOI： 10.1128/aem.58.3.1043-1045.1992

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

12 in total

Review 1. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.

Authors: D A Hopwood; D H Sherman
Journal: Annu Rev Genet Date: 1990 Impact factor: 16.830

2. Nitrogen inhibition of mycotoxin production by Alternaria alternata.

Authors: M Orvehed; P Häggblom; K Söderhäll
Journal: Appl Environ Microbiol Date: 1988-10 Impact factor: 4.792

3. Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast.

Authors: T Ono; T Kesado; J Awaya; S Omura
Journal: Biochem Biophys Res Commun Date: 1974-04-23 Impact factor: 3.575

4. Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase.

Authors: G D'Agnolo; I S Rosenfeld; J Awaya; S Omura; P R Vagelos
Journal: Biochim Biophys Acta Date: 1973-11-29

1. Inactivation of the polyketide synthase, 6-methylsalicylic acid synthase, by the specific modification of Cys-204 of the beta-ketoacyl synthase by the fungal mycotoxin cerulenin.

Authors: C J Child; P M Shoolingin-Jordan
Journal: Biochem J Date: 1998-03-01 Impact factor: 3.857

Review 2. Detoxification of Mycotoxins through Biotransformation.

Authors: Peng Li; Ruixue Su; Ruya Yin; Daowan Lai; Mingan Wang; Yang Liu; Ligang Zhou
Journal: Toxins (Basel) Date: 2020-02-14 Impact factor: 4.546

2 in total

Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin.

Review 1. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.

2. Nitrogen inhibition of mycotoxin production by Alternaria alternata.

3. Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast.

4. Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase.

5. Inhibition of the biosynthesis of leucomycin, a macrolide antibiotic, by cerulenin.

6. Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata.

7. Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin.

8. Binding site of cerulenin in fatty acid synthetase.

9. Specific inhibition of candicidin biosynthesis by the lipogenic inhibitor cerulenin.

10. Blue light inhibits mycotoxin production and increases total lipids and pigmentation in Alternaria alternata.

1. Inactivation of the polyketide synthase, 6-methylsalicylic acid synthase, by the specific modification of Cys-204 of the beta-ketoacyl synthase by the fungal mycotoxin cerulenin.

Review 2. Detoxification of Mycotoxins through Biotransformation.