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Literature DB >> 15754006

Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.

Ajai Pal¹, Ateeq Ahmad, Sumsullah Khan, Isamu Sakabe, Chuanbo Zhang, Usha N Kasid, Imran Ahmad.

Abstract

Raf-1, a protein serine-threonine kinase, plays a critical role in mitogen-activated protein kinase kinase (MKK/MEK)- mitogen-activated protein kinase (extracellular signal-regulated kinase) (MAPK/ERK) pathways. We show here that systemically delivered novel cationic cardiolipin liposomes (NeoPhectin-AT) containing a small interfering RNA (siRNA) against Raf-1 silence the expression of Raf-1 in tumor tissues and inhibit tumor growth in xenograft model of human prostate cancer. The knockdown of Raf-1 expression by siRNA is also associated with down-regulation of cyclin D1 expression in vivo.

Entities: Disease Gene Species

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Year: 2005 PMID： 15754006

Source DB: PubMed Journal: Int J Oncol ISSN： 1019-6439 Impact factor: 5.650

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Cited

31 in total

Review 1. Nonviral delivery of synthetic siRNAs in vivo.

Authors: Saghir Akhtar; Ibrahim F Benter
Journal: J Clin Invest Date: 2007-12 Impact factor: 14.808

Review 2. Selective Raf inhibition in cancer therapy.

Authors: Vladimir Khazak; Igor Astsaturov; Ilya G Serebriiskii; Erica A Golemis
Journal: Expert Opin Ther Targets Date: 2007-12 Impact factor: 6.902

3. MiR-7-5p is frequently downregulated in glioblastoma microvasculature and inhibits vascular endothelial cell proliferation by targeting RAF1.

Authors: Zhiguo Liu; Yuguang Liu; Lianling Li; Zhenkuan Xu; Baibin Bi; Yunyan Wang; Jian Yi Li
Journal: Tumour Biol Date: 2014-07-16

Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer.

Review 1. Nonviral delivery of synthetic siRNAs in vivo.

Review 2. Selective Raf inhibition in cancer therapy.

3. MiR-7-5p is frequently downregulated in glioblastoma microvasculature and inhibits vascular endothelial cell proliferation by targeting RAF1.

Review 4. Self-assembled and nanostructured siRNA delivery systems.

5. Buffering capacity and size of siRNA polyplexes influence cytokine levels.

Review 6. Cholesterol as a potential target for castration-resistant prostate cancer.

Review 7. Self-assembled lipid nanomedicines for siRNA tumor targeting.

8. Influence of two transfectors on delivery of 99mTc antisense DNA in tumor-bearing mice.

9. Aptamer-targeted cell-specific RNA interference.

Review 10. Use of liposomes as drug delivery vehicles for treatment of melanoma.