Literature DB >> 15753178

Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells.

Carmela Conte1, Alessandro Floridi, Cristina Aisa, Marta Piroddi, Ardesio Floridi, Francesco Galli.   

Abstract

In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T<alpha-T3<gamma-T<gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.

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Year:  2004        PMID： 15753178     DOI： 10.1196/annals.1331.054

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  12 in total

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Review 6.  Vitamin E: a dark horse at the crossroad of cancer management.

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7.  Dietary terpenoids and prostate cancer chemoprevention.

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10.  Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways.

Authors:  W N Yap; P N Chang; H Y Han; D T W Lee; M T Ling; Y C Wong; Y L Yap
Journal:  Br J Cancer       Date:  2008-11-11       Impact factor: 7.640
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