| Literature DB >> 15752474 |
A Malenovic1, M Medenica, D Ivanovic, B Jancic, S Markovic.
Abstract
The simple and rapid RP-HPLC method, for the simultaneous determination of lidocaine and cetrimonium bromide in the presence of pellet color corrigent, was developed. Separations were performed on a Beckman Ultrasphere ODS 4.6 mm x 15 cm, 5 microm particle column at 40 degrees C. The mobile phase consisted of water phase and acetonitrile (72:28 V/V), pH value of the mobile phase was adjusted to 2.0 with 85% ortophosphoric acid. Bisacodil was used as an internal standard. The flow rate was 1 ml/min and UV detection was performed at 208 nm. The proposed RP-HPLC method was validated and all the parameters for the validation of the method are given. According to the obtained results, the developed method was found to be suitable and accurate for the determination of these drugs in commercial formulations.Entities:
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Year: 2005 PMID： 15752474 DOI： 10.1016/j.farmac.2004.11.004
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X