[Recent trend of diagnosis and treatment for Zollinger-Ellison syndrome].

Since 1955 it has been difficult to cure gastrinomas in patients with Zollinger-Ellison Syndrome (ZES), because gastrinomas exhibit symptoms when they are still small. Besides they are often multiple and metastatic. Development of the SASI test and SRS has changed the situation, and now, based on these two techniques, curative resection of gastrinomas in ZES can be routinely performed. As the cases of resection increase, more accurate pathological findings have accumulated. We know now that duodenal gastrinomas have been a cause of ZES in more patients than pancreatic gastrinomas. In most patients with MEN-1 and ZES, duodenal gastrinomas, which are often multiple, bring about ZES.