Literature DB >> 15750602

Essential Ca(V)beta modulatory properties are AID-independent.

Janet M Maltez1, Deborah A Nunziato, James Kim, Geoffrey S Pitt.   

Abstract

Voltage-gated Ca(2+) channel beta (Ca(v)beta) subunits have a highly conserved core consisting of interacting Src homology 3 and guanylate kinase domains, and are postulated to exert their effects through AID, the major interaction site in the pore-forming alpha(1) subunit. This stereotypical interaction does not explain how individual Ca(v)beta subunits modulate alpha(1) subunits differentially. Here we show that AID is neither necessary nor sufficient for critical Ca(v)beta regulatory properties. Complete modulation depends on additional contacts that are exclusive of AID and not revealed in recent crystal structures. These data offer a new context for understanding Ca(v)beta modulation, suggesting that the AID interaction orients the Ca(v)beta core so as to permit additional isoform-specific Ca(v)alpha(1)-Ca(v)beta interactions that underlie the particular regulation seen with each Ca(v)alpha(1)-Ca(v)beta pair, rather than as the main site of regulation.

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Year:  2005        PMID： 15750602     DOI： 10.1038/nsmb909

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  39 in total

1.  Single-channel monitoring of reversible L-type Ca(2+) channel Ca(V)α(1)-Ca(V)β subunit interaction.

Authors:  Wanchana Jangsangthong; Elza Kuzmenkina; Ann Kristin Böhnke; Stefan Herzig
Journal:  Biophys J       Date:  2011-12-07       Impact factor: 4.033

Review 2.  Trafficking and stability of voltage-gated calcium channels.

Authors:  Brett A Simms; Gerald W Zamponi
Journal:  Cell Mol Life Sci       Date:  2011-10-02       Impact factor: 9.261

3.  Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction.

Authors:  Mingming Fan; Zafir Buraei; Huai-Rong Luo; Rose Levenson-Palmer; Jian Yang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

4.  The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels.

Authors:  Christophe Altier; Agustin Garcia-Caballero; Brett Simms; Haitao You; Lina Chen; Jan Walcher; H William Tedford; Tamara Hermosilla; Gerald W Zamponi
Journal:  Nat Neurosci       Date:  2010-12-26       Impact factor: 24.884

Review 5.  The ß subunit of voltage-gated Ca2+ channels.

Authors:  Zafir Buraei; Jian Yang
Journal:  Physiol Rev       Date:  2010-10       Impact factor: 37.312

6.  Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit.

Authors:  Andrew C Vendel; Christopher D Rithner; Barbara A Lyons; William A Horne
Journal:  Protein Sci       Date:  2005-12-29       Impact factor: 6.725

7.  The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function.

Authors:  Adrian J Butcher; Jérôme Leroy; Mark W Richards; Wendy S Pratt; Annette C Dolphin
Journal:  J Physiol       Date:  2006-04-20       Impact factor: 5.182

8.  The structural biology of voltage-gated calcium channel function and regulation.

Authors:  F Van Petegem; D L Minor
Journal:  Biochem Soc Trans       Date:  2006-11       Impact factor: 5.407

9.  A quartet of leucine residues in the guanylate kinase domain of CaVβ determines the plasma membrane density of the CaV2.3 channel.

Authors:  Behzad Shakeri; Benoîte Bourdin; Pierre-Olivier Demers-Giroux; Rémy Sauvé; Lucie Parent
Journal:  J Biol Chem       Date:  2012-07-30       Impact factor: 5.157

10.  Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits.

Authors:  Chad E Grueter; Sunday A Abiria; Yunji Wu; Mark E Anderson; Roger J Colbran
Journal:  Biochemistry       Date:  2008-01-19       Impact factor: 3.162
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