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Literature DB >> 15750589

Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons.

Sara J Aton¹, Christopher S Colwell, Anthony J Harmar, James Waschek, Erik D Herzog.

Abstract

The mammalian suprachiasmatic nucleus (SCN) is a master circadian pacemaker. It is not known which SCN neurons are autonomous pacemakers or how they synchronize their daily firing rhythms to coordinate circadian behavior. Vasoactive intestinal polypeptide (VIP) and the VIP receptor VPAC(2) (encoded by the gene Vipr2) may mediate rhythms in individual SCN neurons, synchrony between neurons, or both. We found that Vip(-/-) and Vipr2(-/-) mice showed two daily bouts of activity in a skeleton photoperiod and multiple circadian periods in constant darkness. Loss of VIP or VPAC(2) also abolished circadian firing rhythms in approximately half of all SCN neurons and disrupted synchrony between rhythmic neurons. Critically, daily application of a VPAC(2) agonist restored rhythmicity and synchrony to VIP(-/-) SCN neurons, but not to Vipr2(-/-) neurons. We conclude that VIP coordinates daily rhythms in the SCN and behavior by synchronizing a small population of pacemaking neurons and maintaining rhythmicity in a larger subset of neurons.

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Year: 2005 PMID： 15750589 PMCID： PMC1628303 DOI： 10.1038/nn1419

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

48 in total

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Review 6. VIP as a trophic factor in the CNS and cancer cells.

Authors: Terry W Moody; Joanna M Hill; Robert T Jensen
Journal: Peptides Date: 2003-01 Impact factor: 3.750

7. Regulation of inhibitory synaptic transmission by vasoactive intestinal peptide (VIP) in the mouse suprachiasmatic nucleus.

Authors: Jason Itri; Christopher S Colwell
Journal: J Neurophysiol Date: 2003-09 Impact factor: 2.714

8. The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro.

Authors: David J Cutler; Mai Haraura; Helen E Reed; Sanbing Shen; W John Sheward; Christine F Morrison; Hugh M Marston; Anthony J Harmar; Hugh D Piggins
Journal: Eur J Neurosci Date: 2003-01 Impact factor: 3.386

9. The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.

Authors: Anthony J Harmar; Hugh M Marston; Sanbing Shen; Christopher Spratt; Katrine M West; W John Sheward; Christine F Morrison; Julia R Dorin; Hugh D Piggins; Jean Claude Reubi; John S Kelly; Elizabeth S Maywood; Michael H Hastings
Journal: Cell Date: 2002-05-17 Impact factor: 41.582

10. Effects of vasoactive intestinal polypeptide on neurones of the rat suprachiasmatic nuclei in vitro.

Authors: H E Reed; D J Cutler; T M Brown; J Brown; C W Coen; H D Piggins
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302 in total

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6. Chronic stimulation of the hypothalamic vasoactive intestinal peptide receptor lengthens circadian period in mice and hamsters.

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7. Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.

Authors: Yong-Jun Liu; Yan-Fang Guo; Li-Shu Zhang; Yu-Fang Pei; Na Yu; Ping Yu; Christopher J Papasian; Hong-Wen Deng
Journal: Obesity (Silver Spring) Date: 2010-04-08 Impact factor: 5.002