Literature DB >> 15749685

Five prothrombotic polymorphisms and the prevalence of premature myocardial infarction.

Vanessa Roldán, Rocío González-Conejero, Francisco Marín, Javier Pineda, Vicente Vicente, Javier Corral.   

Abstract

We studied 5 functional hemostatic polymorphisms in 281 patients with premature myocardial infarction and in 530 control subjects. The role of these polymorphisms when analyzed independently is small, if any. However, the simultaneous combination of factor XIII and prothrombin polymorphisms exacerbated the risk. (OR=12.12; p=0.028). Moreover, combinations of factor V Leiden with prothrombin, and factor XII with prothrombin polymorphisms were only identified in patients. Our results support the relevance of gene-gene interactions in myocardial infarction.

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Year:  2005        PMID： 15749685

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  9 in total

1.  Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls.

Authors:  Bo Jin; Yong Li; Qu-Zhen Ge-Shang; Huan-Chun Ni; Hai-Ming Shi; Wei Shen
Journal:  Mol Biol Rep       Date:  2010-11-16       Impact factor: 2.316

2.  An ensemble learning approach jointly modeling main and interaction effects in genetic association studies.

Authors:  Zhaogong Zhang; Shuanglin Zhang; Man-Yu Wong; Nicholas J Wareham; Qiuying Sha
Journal:  Genet Epidemiol       Date:  2008-05       Impact factor: 2.135

3.  Factor XIII-A Val34Leu polymorphism might beassociated with myocardial infarction risk: an updated meta-analysis.

Authors:  Guangyun Wang; Zhikang Zou; Xiucai Ji; Qingshan Ni; Zhongli Ma
Journal:  Int J Clin Exp Med       Date:  2014-12-15

4.  A testing framework for identifying susceptibility genes in the presence of epistasis.

Authors:  Joshua Millstein; David V Conti; Frank D Gilliland; W James Gauderman
Journal:  Am J Hum Genet       Date:  2005-11-11       Impact factor: 11.025

5.  Multiple thrombophilia mutations as a possible cause of premature myocardial infarction.

Authors:  Gabriela Dostálová; Jan Bělohlávek; Zuzana Hlubocká; Kristýna Bayerová; Petra Bobčiková; Tomáš Kvasnička; Jan Kvasnička; Aleš Linhart; Debora Karetová
Journal:  Wien Klin Wochenschr       Date:  2017-04-05       Impact factor: 1.704

6.  Identification of interacting genes in genome-wide association studies using a model-based two-stage approach.

Authors:  Zhaogong Zhang; Adan Niu; Qiuying Sha
Journal:  Ann Hum Genet       Date:  2010-07-15       Impact factor: 1.670

7.  Multiplex assay for genetic testing of thrombophilia: a method for routine clinical care.

Authors:  Mónica López; Pilar Giraldo; Patricia Alvarez; R Cornudella; Miguel Pocoví; Antonio Martínez; Jordi Fontcuberta; José Manuel Soria
Journal:  J Clin Lab Anal       Date:  2007       Impact factor: 2.352

8.  Prothrombin G20210A (rs1799963) polymorphism increases myocardial infarction risk in an age-related manner: A systematic review and meta-analysis.

Authors:  Changlong Li; Hui Ren; Hong Chen; Junxian Song; Sufang Li; Chongyou Lee; Jun Liu; Yuxia Cui
Journal:  Sci Rep       Date:  2017-10-19       Impact factor: 4.379

9.  Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis.

Authors:  Qiuying Sha; Zhaogong Zhang; Jennifer C Schymick; Bryan J Traynor; Shuanglin Zhang
Journal:  BMC Med Genet       Date:  2009-09-09       Impact factor: 2.103
  9 in total

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