Literature DB >> 15749057

Regulatory enzymes of phosphatidylcholine biosynthesis: a personal perspective.

Claudia Kent1.   

Abstract

Phosphatidylcholine is a prominent constituent of eukaryotic and some prokaryotic membranes. This Perspective focuses on the two enzymes that regulate its biosynthesis, choline kinase and CTP:phosphocholine cytidylyltransferase. These enzymes are discussed with respect to their molecular properties, isoforms, enzymatic activities, and structures, and the possible molecular mechanisms by which they participate in regulation of phosphatidylcholine levels in the cell.

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Year:  2005        PMID: 15749057     DOI: 10.1016/j.bbalip.2004.12.008

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  33 in total

Review 1.  Nematode phospholipid metabolism: an example of closing the genome-structure-function circle.

Authors:  Soon Goo Lee; Joseph M Jez
Journal:  Trends Parasitol       Date:  2014-03-28

2.  ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.

Authors:  Hemamalini Bommiasamy; Sung Hoon Back; Paolo Fagone; Kyungho Lee; Sasha Meshinchi; Elizabeth Vink; Rungtawan Sriburi; Matthew Frank; Suzanne Jackowski; Randal J Kaufman; Joseph W Brewer
Journal:  J Cell Sci       Date:  2009-05-15       Impact factor: 5.285

3.  Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold.

Authors:  Jaeyong Lee; Joanne Johnson; Ziwei Ding; Mark Paetzel; Rosemary B Cornell
Journal:  J Biol Chem       Date:  2009-09-25       Impact factor: 5.157

4.  Polyvalent choline phosphate as a universal biomembrane adhesive.

Authors:  Xifei Yu; Zonghua Liu; Johan Janzen; Irina Chafeeva; Sonja Horte; Wei Chen; Rajesh K Kainthan; Jayachandran N Kizhakkedathu; Donald E Brooks
Journal:  Nat Mater       Date:  2012-03-18       Impact factor: 43.841

5.  The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer.

Authors:  Xinchun Zhou; Thomas J Lawrence; Zhi He; Charles R Pound; Jinghe Mao; Steven A Bigler
Journal:  Exp Mol Pathol       Date:  2011-11-11       Impact factor: 3.362

6.  Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy.

Authors:  Guilherme L Yamamoto; Wagner A R Baratela; Tatiana F Almeida; Monize Lazar; Clara L Afonso; Maria K Oyamada; Lisa Suzuki; Luiz A N Oliveira; Ester S Ramos; Chong A Kim; Maria Rita Passos-Bueno; Débora R Bertola
Journal:  Am J Hum Genet       Date:  2014-01-02       Impact factor: 11.025

7.  PHOSPHATIDIC ACID PHOSPHOHYDROLASE Regulates Phosphatidylcholine Biosynthesis in Arabidopsis by Phosphatidic Acid-Mediated Activation of CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE Activity.

Authors:  Christian P Craddock; Nicolette Adams; Fiona M Bryant; Smita Kurup; Peter J Eastmond
Journal:  Plant Cell       Date:  2015-04-10       Impact factor: 11.277

Review 8.  Skeletal muscle lipid flux: running water carries no poison.

Authors:  Katsuhiko Funai; Clay F Semenkovich
Journal:  Am J Physiol Endocrinol Metab       Date:  2011-05-10       Impact factor: 4.310

9.  Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase.

Authors:  Jay D Braker; Kevin J Hodel; David R Mullins; Jon A Friesen
Journal:  Arch Biochem Biophys       Date:  2009-10-23       Impact factor: 4.013

10.  Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.

Authors:  Manu V Chakravarthy; Irfan J Lodhi; Li Yin; Raghu R V Malapaka; H Eric Xu; John Turk; Clay F Semenkovich
Journal:  Cell       Date:  2009-07-30       Impact factor: 41.582

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