Literature DB >> 15748840

Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.

P W Kalivas1, N Volkow, J Seamans.   

Abstract

Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underlie these cardinal features of addiction. A hypothesis is articulated that altered G protein signaling in the PFC focuses behavior on drug-associated stimuli, while dysregulated PFC-accumbens synaptic glutamate transmission underlies the unmanageable motivation to seek drugs.

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Year:  2005        PMID： 15748840     DOI： 10.1016/j.neuron.2005.02.005

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  265 in total

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