Hyperimmunoglobulin E syndrome.

A 63-year-old man presented with erythroderma, peripheral blood eosinophilia, elevated serum IgE levels, and a history of dermatitis, furunculosis, and a cold abscess. Hyperimmunoglobulin E syndrome is a rare, multisystem disorder that is characterized by cutaneous and sinopulmonary infections, dermatitis, and elevated serum IgE levels. Traditional therapy includes good skin care, antibiotics for skin and pulmonary infections, incision and drainage of abscesses, and emollients plus topical glucocorticoids for dermatitis.