Literature DB >> 1574803

A novel HLA-haplotype containing a DRB5 gene not associated with DRB1*15 or DRB1*16 alleles.

C Tautz1, D G Marsh, X Baur.   

Abstract

In Caucasians, HLA-DR2 haplotypes usually express two DRB genes encoding the DR specificity. The DRB5 genes are in strong linkage disequilibrium with the respective DRB1*15 or DRB1*16 alleles. So far, no other DRB1 alleles have been found in association with DRB5 genes. Here, we report evidence for a probably recombinant DRB5 haplotype with a DRB1 allele not specific for DR2. From our results the haplotype DQB1*0501, DRB1*0101 and DRB5*0101 seems most likely.

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Year:  1992        PMID： 1574803     DOI： 10.1111/j.1399-0039.1992.tb01913.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  1 in total

1.  The HLA-DRB6*0201 allele of a pseudogene commonly associated with HLA-DR2 specificities is present in an HLA-DRB1*0101-DRB5*0101 haplotype.

Authors:  G F Fischer; I Fae; W F Pickl
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846
  1 in total

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