Literature DB >> 15747698

The effect of am 251, a cannabinoid CB1 receptor antagonist, on food intake in rats.

Maria Rutkowska1.   

Abstract

The anorectic effect of AM 251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-di-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide), a CB1 receptor antagonist, was studied in rats. AM 251 (0.5-2.0 mg/kg i.p.) significantly and dose-dependently reduced food intake in both free-feeding and food-deprived rats. The obtained results support the anorectic activity of CB1 receptors antagonists.

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Year:  2004        PMID： 15747698

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN： 0001-6837            Impact factor:   0.330


  4 in total

1.  Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.

Authors:  Matthew N Hill; Larissa M Froese; Anna C Morrish; Jane C Sun; Stan B Floresco
Journal:  Psychopharmacology (Berl)       Date:  2006-06-03       Impact factor: 4.530

2.  The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats.

Authors:  Janel Hodge; Joshua P Bow; Kimberly S Plyler; V Kiran Vemuri; Ania Wisniecki; John D Salamone; Alexandros Makriyannis; Peter J McLaughlin
Journal:  Behav Brain Res       Date:  2008-06-17       Impact factor: 3.332

3.  Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects.

Authors:  Bin Pan; Peng Zhong; Dalong Sun; Qing-song Liu
Journal:  J Neurosci       Date:  2011-08-03       Impact factor: 6.167

4.  AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion.

Authors:  Adam P Chambers; Henry S Koopmans; Quentin J Pittman; Keith A Sharkey
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739
  4 in total

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