Literature DB >> 15747251

Use of RNA interference to prevent lethal murine west nile virus infection.

Fengwei Bai1, Tian Wang, Utpal Pal, Fukai Bao, L Hannah Gould, Erol Fikrig.   

Abstract

West Nile virus causes fatal encephalitis in humans, mice, and other vertebrates. In the present study, we demonstrate that small interfering RNAs (siRNAs) inhibit West Nile virus replication in vitro. Moreover, the administration of siRNAs to mice by hydrodynamic injection 24 h before challenge with an intraperitoneal inoculum of West Nile virus reduced the viral load and afforded partial protection from lethal infection. These data show the efficacy of the prophylactic use of siRNAs against a viral infection in vivo and suggest new strategies to combat West Nile virus.

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Year:  2005        PMID： 15747251     DOI： 10.1086/428507

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  44 in total

1.  Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus.

Authors:  Stefanie Müller; Stephan Günther
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

2.  Identification of novel target sites and an inhibitor of the dengue virus E protein.

Authors:  Ragothaman Yennamalli; Naidu Subbarao; Thorsten Kampmann; Ross P McGeary; Paul R Young; Bostjan Kobe
Journal:  J Comput Aided Mol Des       Date:  2009-02-25       Impact factor: 3.686

3.  RNA interference inhibits yellow fever virus replication in vitro and in vivo.

Authors:  Carolina C Pacca; Adriana A Severino; Adriano Mondini; Paula Rahal; Solange G P D'avila; José Antonio Cordeiro; Mara Correa Lelles Nogueira; Roberta V M Bronzoni; Maurício L Nogueira
Journal:  Virus Genes       Date:  2009-01-25       Impact factor: 2.332

4.  Development of Antiviral Innate Immunity During In Vitro Differentiation of Mouse Embryonic Stem Cells.

Authors:  William D'Angelo; Dhiraj Acharya; Ruoxing Wang; Jundi Wang; Chandan Gurung; Bohan Chen; Fengwei Bai; Yan-Lin Guo
Journal:  Stem Cells Dev       Date:  2016-03-17       Impact factor: 3.272

5.  Antiviral responses in mouse embryonic stem cells: differential development of cellular mechanisms in type I interferon production and response.

Authors:  Ruoxing Wang; Jundi Wang; Dhiraj Acharya; Amber M Paul; Fengwei Bai; Faqing Huang; Yan-Lin Guo
Journal:  J Biol Chem       Date:  2014-06-25       Impact factor: 5.157

6.  Identification of novel small-molecule inhibitors of West Nile virus infection.

Authors:  Amine O Noueiry; Paul D Olivo; Urszula Slomczynska; Yi Zhou; Ben Buscher; Brian Geiss; Michael Engle; Robert M Roth; Kyung Min Chung; Melanie Samuel; Michael S Diamond
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

7.  Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.

Authors:  Sandesh Subramanya; Sang-Soo Kim; Sojan Abraham; Jiahong Yao; Mukesh Kumar; Priti Kumar; Viraga Haridas; Sang-Kyung Lee; Leonard D Shultz; Dale Greiner; Manjunath N; Premlata Shankar
Journal:  J Virol       Date:  2009-12-16       Impact factor: 5.103

8.  Mouse embryonic stem cells are deficient in type I interferon expression in response to viral infections and double-stranded RNA.

Authors:  Ruoxing Wang; Jundi Wang; Amber M Paul; Dhiraj Acharya; Fengwei Bai; Faqing Huang; Yan-Lin Guo
Journal:  J Biol Chem       Date:  2013-04-11       Impact factor: 5.157

9.  Bio-Conjugated Gold Nanoparticle Based SERS Probe for Ultrasensitive Identification of Mosquito-Borne Viruses Using Raman Fingerprinting.

Authors:  Amber M Paul; Zhen Fan; Sudarson S Sinha; Yongliang Shi; Linda Le; Fengwei Bai; Paresh C Ray
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2015-09-22       Impact factor: 4.126

10.  IL-10 signaling blockade controls murine West Nile virus infection.

Authors:  Fengwei Bai; Terrence Town; Feng Qian; Penghua Wang; Masahito Kamanaka; Tarah M Connolly; David Gate; Ruth R Montgomery; Richard A Flavell; Erol Fikrig
Journal:  PLoS Pathog       Date:  2009-10-09       Impact factor: 6.823
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