Literature DB >> 15745823

Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.

Guy Falardeau1, Hugo Lachance, Annie St-Pierre, Constantin G Yannopoulos, Marc Drouin, Jean Bédard, Laval Chan.   

Abstract

A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15745823     DOI： 10.1016/j.bmcl.2005.01.050

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines.

Authors:  Mallu Lavanya; Chong Lin; Jincheng Mao; Dhakshanamurthy Thirumalai; Sreenath Reddy Aabaka; Xiaojiang Yang; Jinhua Mao; Zhiyu Huang; Jinzhou Zhao
Journal:  Top Curr Chem (Cham)       Date:  2021-02-24

2.  Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines.

Authors:  Alice Mr Bernardino; Alexandre R Azevedo; Luiz Cs Pinheiro; Júlio C Borges; Izabel Cp Paixão; Milene Mesquita; Thiago Ml Souza; Maurício S Dos Santos
Journal:  Org Med Chem Lett       Date:  2012-02-01

3.  An expedient synthesis, acetylcholinesterase inhibitory activity, and molecular modeling study of highly functionalized hexahydro-1,6-naphthyridines.

Authors:  Abdulrahman I Almansour; Raju Suresh Kumar; Natarajan Arumugam; Alireza Basiri; Yalda Kia; Mohamed Ashraf Ali
Journal:  Biomed Res Int       Date:  2015-01-29       Impact factor: 3.411

4.  Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.

Authors:  Mikhail S Novikov; Denis A Babkov; Maria P Paramonova; Anastasia L Khandazhinskaya; Alexander A Ozerov; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Jan Balzarini; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2013-05-16       Impact factor: 3.641

5.  Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives.

Authors:  Ming-Shu Wang; Yi Gong; Zhi-Cheng Yu; Yan-Guang Tian; Lin-Sheng Zhuo; Wei Huang; Neng-Fang She
Journal:  Molecules       Date:  2020-12-01       Impact factor: 4.411

6.  Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.

Authors:  Denis A Babkov; Anastasia L Khandazhinskaya; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Katherine L Seley-Radtke; Mikhail S Novikov
Journal:  Bioorg Med Chem       Date:  2015-09-21       Impact factor: 3.641
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.