Literature DB >> 15745812

3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.

Jonathan R Dimmock1, Umashankar Das, H Inci Gul, Masami Kawase, Hiroshi Sakagami, Zoltán Baráth, Imre Ocsovsky, Joseph Molnár.   

Abstract

The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.

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Year:  2005        PMID： 15745812     DOI： 10.1016/j.bmcl.2005.01.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; Carlota Lopez Cara; Maria Dora Carrion; Jan Balzarini; Ernest Hamel; Giuseppe Basso; Roberta Bortolozzi; Giampietro Viola
Journal:  Bioorg Med Chem Lett       Date:  2010-03-25       Impact factor: 2.823

2.  Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells.

Authors:  Umashankar Das; Alireza Doroudi; H Inci Gul; Hari N Pati; Masami Kawase; Hiroshi Sakagami; Qing Chu; James P Stables; Jonathan R Dimmock
Journal:  Bioorg Med Chem       Date:  2010-02-04       Impact factor: 3.641

3.  E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties.

Authors:  Umashankar Das; Alireza Doroudi; Swagatika Das; Brian Bandy; Jan Balzarini; Erik De Clercq; Jonathan R Dimmock
Journal:  Bioorg Med Chem       Date:  2008-04-16       Impact factor: 3.641

Review 4.  1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.

Authors:  U Das; R K Sharma; J R Dimmock
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

5.  Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.

Authors:  Hari N Pati; Umashankar Das; J Wilson Quail; Masami Kawase; Hiroshi Sakagami; Jonathan R Dimmock
Journal:  Eur J Med Chem       Date:  2007-04-03       Impact factor: 6.514

6.  2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.

Authors:  Umashankar Das; Hari N Pati; Atulya K Panda; Erik De Clercq; Jan Balzarini; Joseph Molnár; Zoltán Baráth; Imre Ocsovszki; Masami Kawase; Li Zhou; Hiroshi Sakagami; Jonathan R Dimmock
Journal:  Bioorg Med Chem       Date:  2009-04-17       Impact factor: 3.641

7.  1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.

Authors:  Umashankar Das; Joseph Molnár; Zoltán Baráth; Zsuzsanna Bata; Jonathan R Dimmock
Journal:  Bioorg Med Chem Lett       Date:  2008-05-16       Impact factor: 2.823

8.  Curcumin: From a controversial "panacea" to effective antineoplastic products.

Authors:  De-Biao Xiang; Kai-Qiang Zhang; Ya-Ling Zeng; Qing-Zi Yan; Zhe Shi; Qin-Hui Tuo; Li-Mei Lin; Bo-Hou Xia; Ping Wu; Duan-Fang Liao
Journal:  Medicine (Baltimore)       Date:  2020-01       Impact factor: 1.817
  8 in total

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