Literature DB >> 15745806

Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin.

Konstantina C Fylaktakidou1, Jean-Marie Lehn, Ruth Greferath, Claude Nicolau.   

Abstract

Nine inositol tripyrophosphate (ITPP) salts have been synthesized. Their ability to act as allosteric effectors of haemoglobin (Hb) has been measured in vitro with free Hb and whole blood. All the synthesized compounds bound to free Hb and were also able to cross, to a certain extent, the plasma membrane of the red blood cells (RBCs) in whole blood samples, lowering the affinity of Hb for oxygen. The oxy-haemoglobin dissociation curves were significantly shifted towards higher values of oxygen partial pressures, both for free Hb and for intracellular Hb in whole blood.

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Year:  2005        PMID： 15745806     DOI： 10.1016/j.bmcl.2005.01.064

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Suppression of hypoxia-induced HIF-1alpha and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes.

Authors:  Claudine Kieda; Ruth Greferath; Claire Crola da Silva; Konstantina C Fylaktakidou; Jean-Marie Lehn; Claude Nicolau
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-06       Impact factor: 11.205

2.  Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate.

Authors:  Andreia Biolo; Ruth Greferath; Deborah A Siwik; Fuzhong Qin; Eugene Valsky; Konstantina C Fylaktakidou; Srinivasu Pothukanuri; Carolina D Duarte; Richard P Schwarz; Jean-Marie Lehn; Claude Nicolau; Wilson S Colucci
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-09       Impact factor: 11.205

Review 3.  Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia.

Authors:  Aude Carreau; Bouchra El Hafny-Rahbi; Agata Matejuk; Catherine Grillon; Claudine Kieda
Journal:  J Cell Mol Med       Date:  2011-06       Impact factor: 5.310

4.  Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin-oxygen affinity modifiers.

Authors:  Mira P Patel; Vincent Siu; Abel Silva-Garcia; Qing Xu; Zhe Li; Donna Oksenberg
Journal:  Drug Des Devel Ther       Date:  2018-06-01       Impact factor: 4.162

5.  Impact of myo-inositol trispyrophosphate (ITPP) on tumour oxygenation and response to irradiation in rodent tumour models.

Authors:  Ly-Binh-An Tran; Thanh-Trang Cao-Pham; Bénédicte F Jordan; Sofie Deschoemaeker; Arne Heyerick; Bernard Gallez
Journal:  J Cell Mol Med       Date:  2018-12-21       Impact factor: 5.310

6.  Combined endogenous MR biomarkers to assess changes in tumor oxygenation induced by an allosteric effector of hemoglobin.

Authors:  Thanh-Trang Cao-Pham; An Tran-Ly-Binh; Arne Heyerick; Catherine Fillée; Nicolas Joudiou; Bernard Gallez; Bénédicte F Jordan
Journal:  NMR Biomed       Date:  2019-11-25       Impact factor: 4.044

7.  Stable tumor vessel normalization with pO₂ increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment.

Authors:  Claudine Kieda; Bouchra El Hafny-Rahbi; Guillaume Collet; Nathalie Lamerant-Fayel; Catherine Grillon; Alan Guichard; Jozef Dulak; Alicja Jozkowicz; Jerzy Kotlinowski; Konstantina C Fylaktakidou; Aurélien Vidal; Philippe Auzeloux; Elisabeth Miot-Noirault; Jean-Claude Beloeil; Jean-Marie Lehn; Claude Nicolau
Journal:  J Mol Med (Berl)       Date:  2013-03-09       Impact factor: 4.599

8.  Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial.

Authors:  Perparim Limani; Michael Linecker; Philipp Kron; Panagiotis Samaras; Bernhard Pestalozzi; Roger Stupp; Alexander Jetter; Philipp Dutkowski; Beat Müllhaupt; Andrea Schlegel; Claude Nicolau; Jean-Marie Lehn; Henrik Petrowsky; Bostjan Humar; Rolf Graf; Pierre-Alain Clavien
Journal:  BMC Cancer       Date:  2016-10-19       Impact factor: 4.430

9.  The 150 most important questions in cancer research and clinical oncology series: questions 76-85 : Edited by Chinese Journal of Cancer.

Authors: 
Journal:  Chin J Cancer       Date:  2017-11-20

10.  Treatment of hypoxia-dependent cardiovascular diseases by myo-inositol trispyrophosphate (ITPP)-enhancement of oxygen delivery by red blood cells.

Authors:  Marta Oknińska; Bouchra El-Hafny-Rahbi; Aleksandra Paterek; Urszula Mackiewicz; Claire Crola-Da Silva; Klaudia Brodaczewska; Michał Mączewski; Claudine Kieda
Journal:  J Cell Mol Med       Date:  2020-01-19       Impact factor: 5.310
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