| Literature DB >> 15745803 |
Ariamala Gopalsamy1, Hui Yang, John W Ellingboe, Hwei-Ru Tsou, Nan Zhang, Erick Honores, Dennis Powell, Miriam Miranda, John P McGinnis, Sridhar K Rabindran.
Abstract
A novel series of p21 chemoselective agents containing a pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides were identified by high throughput screening. Optimization of the amide region by parallel synthesis and the iterative design toward understanding structure-activity relationship to improve potency are described. The isopropyl carbamate derivative 34 was identified as a highly chemoselective agent displaying a potency of 51 nM in the p21 deficient cell line.Entities:
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Year: 2005 PMID： 15745803 DOI： 10.1016/j.bmcl.2005.01.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823