Literature DB >> 15745799

Synthesis of isonicotinic acid N'-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents.

Neelima Sinha1, Sanjay Jain, Ajay Tilekar, Ram Shankar Upadhayaya, Nawal Kishore, Gour Hari Jana, Sudershan K Arora.   

Abstract

A new series of antituberculosis agents 6-9 was designed, synthesized and evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv and clinical isolates in an agar dilution method. Compound 9h showed comparable in vitro activity (MIC) to isoniazid against M. tuberculosis H37Rv and clinical isolates (sensitive strains) and superior activity against resistant strains of M. tuberculosis.

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Year:  2005        PMID： 15745799     DOI： 10.1016/j.bmcl.2005.01.073

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Biological activities of hydrazone derivatives.

Authors:  Sevim Rollas; S Güniz Küçükgüzel
Journal:  Molecules       Date:  2007-08-17       Impact factor: 4.411

2.  Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid.

Authors:  Michael J Hearn; Michael H Cynamon; Michaeline F Chen; Rebecca Coppins; Jessica Davis; Helen Joo-On Kang; Abigail Noble; Becky Tu-Sekine; Marianne S Terrot; Daniella Trombino; Minh Thai; Eleanor R Webster; Rebecca Wilson
Journal:  Eur J Med Chem       Date:  2009-05-21       Impact factor: 6.514

3.  2-(1,3-Dioxoisoindolin-2-yl)acetic acid-N'-[(E)-2-meth-oxy-benzyl-idene]pyridine-4-carbohydrazide (1/1).

Authors:  Shaaban K Mohamed; Muhammad Akhyar Farrukh; Mehmet Akkurt; Mustafa R Albayati; Antar A Abdelhamid
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-07-14

4.  2-(1,3-Dioxoisoindolin-2-yl)acetic acid-N'-[(E)-4-meth-oxy-benzyl-idene]pyridine-4-carbohydrazide (2/1).

Authors:  Sladjana B Novaković; Goran A Bogdanović; Shaaban K Mohamed; Mustafa R Albayati; Ayad S Hameed
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-08
  4 in total

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