Literature DB >> 15745796

3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis.

Irina Shcherbakova1, Manuel F Balandrin, John Fox, Anjan Ghatak, William L Heaton, Rebecca L Conklin.   

Abstract

Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.

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Year:  2005        PMID: 15745796     DOI: 10.1016/j.bmcl.2005.01.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  New concepts in calcium-sensing receptor pharmacology and signalling.

Authors:  Donald T Ward; Daniela Riccardi
Journal:  Br J Pharmacol       Date:  2012-01       Impact factor: 8.739

2.  Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone.

Authors:  Leila Hosseinzadeh; Alireza Aliabadi; Masoud Kalantari; Abolfazl Mostafavi; Marzieh Rahmani Khajouei
Journal:  Res Pharm Sci       Date:  2016 May-Jun

3.  Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study.

Authors:  Amira A El-Sayed; Mahmoud F Ismail; Abd El-Galil E Amr; Ahmed M Naglah
Journal:  Molecules       Date:  2019-10-21       Impact factor: 4.411

4.  Synthesis and cytotoxic evaluation of some new 3-(2-(2-phenylthiazol-4-yl) ethyl)-quinazolin-4(3H) one derivatives with potential anticancer effects.

Authors:  Leila Hosseinzadeh; Alireza Aliabadi; Mohsen Rahnama; Hamid Mir Mohammad Sadeghi; Marzieh Rahmani Khajouei
Journal:  Res Pharm Sci       Date:  2017-08
  4 in total

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