Literature DB >> 15745795

Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.

George Burton1, Thomas W Ku, Thomas J Carr, Terry Kiesow, Robert T Sarisky, Juili Lin-Goerke, Audrey Baker, David L Earnshaw, Glenn A Hofmann, Richard M Keenan, Dashyant Dhanak.   

Abstract

HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase identified two 168 member N-acyl pyrrolidine combinatorial mixture hits. Deconvolution and expansion of these mixtures by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported.

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Year:  2005        PMID： 15745795     DOI： 10.1016/j.bmcl.2005.01.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.

Authors:  Frederik Pauwels; Wendy Mostmans; Ludo M M Quirynen; Liesbet van der Helm; Carlo W Boutton; Anne-Stéphanie Rueff; Erna Cleiren; Pierre Raboisson; Dominique Surleraux; Origène Nyanguile; Kenneth A Simmen
Journal:  J Virol       Date:  2007-04-25       Impact factor: 5.103

2.  Stereoselective Synthesis of Quaternary Proline Analogues.

Authors:  M Isabel Calaza; Carlos Cativiela
Journal:  European J Org Chem       Date:  2008

3.  Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor.

Authors:  María Martín-Rodríguez; Carmen Nájera; José M Sansano; Abel de Cózar; Fernando P Cossío
Journal:  Beilstein J Org Chem       Date:  2011-07-19       Impact factor: 2.883

4.  A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline.

Authors:  Xin Chen; Shanshan Qin; Shuai Chen; Jinlong Li; Lixin Li; Zhongling Wang; Quan Wang; Jianping Lin; Cheng Yang; Wenqing Shui
Journal:  Sci Rep       Date:  2015-02-10       Impact factor: 4.379

5.  Enantiomerically Enriched 1,2-P,N-Bidentate Ferrocenyl Ligands for 1,3-Dipolar Cycloaddition and Transfer Hydrogenation Reactions.

Authors:  Irina A Utepova; Polina O Serebrennikova; Marina S Streltsova; Alexandra A Musikhina; Tatiana G Fedorchenko; Oleg N Chupakhin; Andrey P Antonchick
Journal:  Molecules       Date:  2018-05-30       Impact factor: 4.411

6.  Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.

Authors:  Iwona E Weidlich; Igor V Filippov; Jodian Brown; Neerja Kaushik-Basu; Ramalingam Krishnan; Marc C Nicklaus; Ian F Thorpe
Journal:  Bioorg Med Chem       Date:  2013-03-29       Impact factor: 3.641

7.  Classification of HCV NS5B polymerase inhibitors using support vector machine.

Authors:  Maolin Wang; Kai Wang; Aixia Yan; Changyuan Yu
Journal:  Int J Mol Sci       Date:  2012-03-27       Impact factor: 6.208
  7 in total

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