Literature DB >> 15744522

Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study.

Brent C Taylor1, Pamela J Schreiner, Terence M Doherty, Myriam Fornage, J Jeffrey Carr, Steve Sidney.   

Abstract

A role for matrix proteins has previously been proposed in the pathogenesis of arterial calcification in the setting of atherosclerosis, and a link has been suggested between osteoporosis and arterial calcification. Our aim has been to investigate whether matrix Gla protein (MGP) T-138C, osteopontin (SPP1) T-443C, and Asp94Asp single nucleotide polymorphisms are associated with the development of arterial calcification and bone density. The individual effects of the MGP and SPP1 polymorphisms with coronary calcification are weak and not statistically significant. Bone mineral density differences at both the hip and spine do not vary statistically by genotype for any of the polymorphisms studied. Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease.

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Year:  2005        PMID： 15744522     DOI： 10.1007/s00439-005-1258-3

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study.

Authors:  J Jeffrey Carr; Jennifer Clark Nelson; Nathan D Wong; Michael McNitt-Gray; Yadon Arad; David R Jacobs; Stephan Sidney; Diane E Bild; O Dale Williams; Robert C Detrano
Journal:  Radiology       Date:  2005-01       Impact factor: 11.105

2.  Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques.

Authors:  C R Dhore; J P Cleutjens; E Lutgens; K B Cleutjens; P P Geusens; P J Kitslaar; J H Tordoir; H M Spronk; C Vermeer; M J Daemen
Journal:  Arterioscler Thromb Vasc Biol       Date:  2001-12       Impact factor: 8.311

3.  The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study.

Authors:  A E Canfield; C Farrington; M D Dziobon; R P Boot-Handford; A M Heagerty; S N Kumar; I S D Roberts
Journal:  J Pathol       Date:  2002-02       Impact factor: 7.996

4.  Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.

Authors:  G Luo; P Ducy; M D McKee; G J Pinero; E Loyer; R R Behringer; G Karsenty
Journal:  Nature       Date:  1997-03-06       Impact factor: 49.962

5.  Polymorphisms in the osteopontin promoter affect its transcriptional activity.

Authors:  Francesca Giacopelli; Renato Marciano; Angela Pistorio; Paolo Catarsi; Silvana Canini; Gerard Karsenty; Roberto Ravazzolo
Journal:  Physiol Genomics       Date:  2004-10-12       Impact factor: 3.107

6.  CARDIA: study design, recruitment, and some characteristics of the examined subjects.

Authors:  G D Friedman; G R Cutter; R P Donahue; G H Hughes; S B Hulley; D R Jacobs; K Liu; P J Savage
Journal:  J Clin Epidemiol       Date:  1988       Impact factor: 6.437

7.  Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography.

Authors:  Shuichi Jono; Yuji Ikari; Cees Vermeer; Paul Dissel; Kotaro Hasegawa; Atsushi Shioi; Hiromichi Taniwaki; Akane Kizu; Yoshiki Nishizawa; Shigeru Saito
Journal:  Thromb Haemost       Date:  2004-04       Impact factor: 5.249

Review 8.  Molecular, endocrine, and genetic mechanisms of arterial calcification.

Authors:  Terence M Doherty; Lorraine A Fitzpatrick; Daisuke Inoue; Jian-Hua Qiao; Michael C Fishbein; Robert C Detrano; Prediman K Shah; Tripathi B Rajavashisth
Journal:  Endocr Rev       Date:  2004-08       Impact factor: 19.871

9.  Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo.

Authors:  Mei Y Speer; Marc D McKee; Robert E Guldberg; Lucy Liaw; Hsueh-Ying Yang; Elyse Tung; Gerard Karsenty; Cecilia M Giachelli
Journal:  J Exp Med       Date:  2002-10-21       Impact factor: 14.307
  9 in total
  17 in total

1.  Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification.

Authors:  Christopher J O'Donnell; M Kyla Shea; Paul A Price; David R Gagnon; Peter W F Wilson; Martin G Larson; Douglas P Kiel; Udo Hoffmann; Maros Ferencik; Melvin E Clouse; Matthew K Williamson; L Adrienne Cupples; Bess Dawson-Hughes; Sarah L Booth
Journal:  Arterioscler Thromb Vasc Biol       Date:  2006-09-14       Impact factor: 8.311

Review 2.  Genetics of cardiovascular disease: Importance of sex and ethnicity.

Authors:  Stacey J Winham; Mariza de Andrade; Virginia M Miller
Journal:  Atherosclerosis       Date:  2015-03-16       Impact factor: 5.162

3.  Matrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis.

Authors:  Devyani Misra; Sarah L Booth; Micheal D Crosier; Jose M Ordovas; David T Felson; Tuhina Neogi
Journal:  J Rheumatol       Date:  2011-07-01       Impact factor: 4.666

4.  Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study.

Authors:  Virginia M Miller; Tanya M Petterson; Elysia N Jeavons; Abhinita S Lnu; David N Rider; John A Heit; Julie M Cunningham; Gordon S Huggins; Howard N Hodis; Matthew J Budoff; Nanette Santoro; Paul N Hopkins; Rogerio A Lobo; JoAnn E Manson; Frederick Naftolin; Hugh S Taylor; S Mitchell Harman; Mariza de Andrade
Journal:  Physiol Genomics       Date:  2012-11-27       Impact factor: 3.107

Review 5.  Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.

Authors:  Frank Rutsch; Yvonne Nitschke; Robert Terkeltaub
Journal:  Circ Res       Date:  2011-08-19       Impact factor: 17.367

6.  Genetic variation and atherosclerosis.

Authors:  Erik Biros; Mirko Karan; Jonathan Golledge
Journal:  Curr Genomics       Date:  2008-03       Impact factor: 2.236

7.  Matrix Gla protein polymorphisms are associated with coronary artery calcification in men.

Authors:  Michael D Crosier; Sarah L Booth; Inga Peter; Bess Dawson-Hughes; Paul A Price; Christopher J O'Donnell; Udo Hoffmann; Matthew K Williamson; Jose M Ordovas
Journal:  J Nutr Sci Vitaminol (Tokyo)       Date:  2009-02       Impact factor: 2.000

8.  Association of matrix Gla protein gene allelic polymorphisms (G(-7)→A, T(-138)→C and Thr(83)→Ala) with acute coronary syndrome in the Ukrainian population.

Authors:  Victoria Yu Garbuzova; Veronika L Gurianova; Dmitriy A Stroy; Victor E Dosenko; Alexander N Parkhomenko; Alexander V Ataman
Journal:  Exp Clin Cardiol       Date:  2012

9.  Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study.

Authors:  Barry I Freedman; Donald W Bowden; Julie T Ziegler; Carl D Langefeld; Allison B Lehtinen; Megan E Rudock; Leon Lenchik; Keith A Hruska; Thomas C Register; J Jeffrey Carr
Journal:  J Bone Miner Res       Date:  2009-10       Impact factor: 6.741

10.  Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study.

Authors:  J Jeffrey Carr; Thomas C Register; Fang-Chi Hsu; Kurt Lohman; Leon Lenchik; Donald W Bowden; Carl D Langefeld; Jianzhou Xu; Stephen S Rich; Lynne E Wagenknecht; Barry I Freedman
Journal:  Bone       Date:  2007-08-22       Impact factor: 4.398
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