Literature DB >> 15744110

Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity.

Tepy Usia, Shigetoshi Kadota, Yasuhiro Tezuka.   

Abstract

A new sesquiterpene 2,9-humuladien-6-ol-8-one (1) was isolated from methanol extract of Zingiber aromaticum, along with 15 known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibitory activity on the metabolism mediated by cytochrome P450 3A4 (CYP3A4) and CYP2D6.

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Year:  2005        PMID: 15744110     DOI: 10.1248/cpb.53.333

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  2 in total

1.  Molecular analysis and modeling of inactivation of human CYP2D6 by four mechanism based inactivators.

Authors:  Mara Livezey; Leslie D Nagy; Laura E Diffenderfer; Evan J Arthur; David J Hsi; Jeffrey M Holton; Laura Lowe Furge
Journal:  Drug Metab Lett       Date:  2012-03

2.  Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions.

Authors:  David Picking; Bentley Chambers; James Barker; Iltaf Shah; Roy Porter; Declan P Naughton; Rupika Delgoda
Journal:  Molecules       Date:  2018-02-15       Impact factor: 4.411

  2 in total

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